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. 1989;30(6):452-7.
doi: 10.1007/BF02421177.

Molecular cloning and chromosomal assignment of a human perforin (PFP) gene

Y Shinkai  1 , M C Yoshida, K Maeda, T Kobata, K Maruyama, J Yodoi, H Yagita, K Okumura
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Molecular cloning and chromosomal assignment of a human perforin (PFP) gene

Y Shinkai et al. Immunogenetics. 1989.

Abstract

Human perforin cDNA was isolated and the complete nucleotide sequence of the gene determined. The deduced amino acid sequence of human perforin showed 68.4% similarity to that of mouse perforin. RNA blot analysis of the human perforin gene revealed that the gene product is expressed preferentially in killer-type cells among cell lines tested, and in large granular lymphocytes among the peripheral blood mononuclear cells. In situ hybridization analysis with a human perforin cDNA probe revealed that the human perforin (PFP) gene is located on chromosome 17q11-21.

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