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Case Reports
. 2015 May-Jun;15(3):302-4.
doi: 10.1016/j.pan.2015.03.016. Epub 2015 Apr 9.

EBV-associated lymphoepithelioma-like carcinoma of the pancreas: Case report with targeted sequencing analysis

Rashmi T Samdani  1 , Jaclyn F Hechtman  2 , Eileen O'Reilly  3 , Ronald DeMatteo  4 , Carlie S Sigel  5
Affiliations
Case Reports

EBV-associated lymphoepithelioma-like carcinoma of the pancreas: Case report with targeted sequencing analysis

Rashmi T Samdani et al. Pancreatology. 2015 May-Jun.

Abstract

Lymphoepithelioma-like carcinomas are distinctive epithelial derived malignant neoplasms that have a syncytial growth pattern and lymphoid stroma. The majority of tumors with this appearance are Epstein Barr virus (EBV)-associated. We report a patient with a clinical presentation concerning for lymphoma who was diagnosed with an EBV-associated pancreatic carcinoma with a lymphoepithelioma-like pattern. Targeted sequencing analysis showed a molecular profile distinct from conventional ductal adenocarcinoma of the pancreas.

Keywords: EBV-associated carcinoma; Epstein Barr virus; Lymphoepithelial-like carcinoma; Lymphoepithelioma-like carcinoma; Pancreas carcinoma; Targeted molecular analysis.

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Figures

Figure
Figure
1A) MRI of the abdomen revealed a 3 cm mass in the uncinate of the pancreas with a dilated bile duct (*) and a dilated pancreas duct (^). 1B) The radiologic lesion corresponded to a 3.2 cm mass in the resected pancreas (Hematoxylin and eosin stain, 20x). 1C) The histologic findings included sheets of tumor cells with a prominent lymphoid stroma. 1D) In situ hybridization for EBV encoded RNA was positive in the malignant epithelial cells.
See this image and copyright information in PMC

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