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Review
. 2015 Apr;3(2):106-20.
doi: 10.1177/2050640614561668.

Screening for celiac disease in the general population and in high-risk groups

Jonas F Ludvigsson  1 , Timothy R Card  2 , Katri Kaukinen  3 , Julio Bai  4 , Fabiana Zingone  5 , David S Sanders  6 , Joseph A Murray  7
Affiliations
Review

Screening for celiac disease in the general population and in high-risk groups

Jonas F Ludvigsson et al. United European Gastroenterol J. 2015 Apr.

Abstract

Background: Celiac disease (CD) occurs in approximately 1% of the Western population. It is a lifelong disorder that is associated with impaired quality of life (QOL) and an excessive risk of comorbidity and death.

Objectives: To review the literature on screening for CD in relation to the current World Health Organization (WHO) criteria for mass screening.

Methods: We performed a PubMed search to identify indexed papers on CD screening with a publication date from 1900 until 1 June 2014. When we deemed an abstract relevant, we read the corresponding paper in detail.

Results: CD fulfills several WHO criteria for mass screening (high prevalence, available treatment and difficult clinical detection), but it has not yet been established that treatment of asymptomatic CD may reduce the excessive risk of severe complications, leading to higher QOL nor that it is cost-effective.

Conclusions: Current evidence is not sufficient to support mass screening for CD, but active case-finding may be appropriate, as we recognize that most patients with CD will still be missed by this strategy. Although proof of benefit is still lacking, screening for CD may be appropriate in high-risk groups.

Keywords: Celiac disease; World Health Organization; gluten; gluten-free diet; prevention; quality of life; review; risk; screening.

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References

    1. Maki M, Mustalahti K, Kokkonen J, et al. Prevalence of celiac disease among children in Finland. N Engl J Med 2003; 348: 2517–2524. - PubMed
    1. Walker MM, Murray JA, Ronkainen J, et al. Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. Gastroenterology 2010; 139: 112–119. - PMC - PubMed
    1. Mustalahti K, Catassi C, Reunanen A, et al. The prevalence of celiac disease in Europe: Results of a centralized, international mass screening project. Ann Med 2010; 42: 587–595. - PubMed
    1. Murray JA, Van Dyke C, Plevak MF, et al. Trends in the identification and clinical features of celiac disease in a North American community, 1950–2001. Clin Gastroenterol Hepatol 2003; 1: 19–27. - PubMed
    1. Lohi S, Mustalahti K, Kaukinen K, et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther 2007; 26: 1217–1225. - PubMed