Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Apr;3(2):182-9.
doi: 10.1177/2050640615571021.

Incidence and distribution of coeliac disease in Campania (Italy): 2011-2013

Fabiana Zingone  1 , Joe West  2 , Renata Auricchio  3 , Rosa Maria Bevilacqua  3 , Guido Bile  3 , Patrizia Borgheresi  3 , Maria Erminia Bottiglieri  3 , Mariano Caldore  3 , Giuseppe Capece  3 , Maria Cristina Caria  3 , Antonio Crudele  3 , Rosario Cuomo  3 , Maria Lucia Garofano  3 , Nicola Giardullo  3 , Antonietta Gerarda Gravina  3 , Luigi Greco  3 , Patrizia Iannotta  3 , Paolo Kosova  3 , Roberto Lamanda  3 , Basilio Malamisura  3 , Riccardo Marmo  3 , Gianfranco Napoli  3 , Gerardo Nardone  3 , Maria Pacelli  3 , Filomena Pascarella  3 , Elisabetta Riccio  3 , Gabriele Riegler  3 , Antonio Rispo  3 , Alba Rocco  3 , Marco Romano  3 , Ottavio Saffiotti  3 , Paola Saviano  3 , Italo Sorrentini  3 , Pietro Speranza  3 , Carlo Tolone  3 , Raffaella Tortora  3 , Riccardo Troncone  3 , Carolina Ciacci  4
Affiliations

Incidence and distribution of coeliac disease in Campania (Italy): 2011-2013

Fabiana Zingone et al. United European Gastroenterol J. 2015 Apr.

Abstract

Background: There exists a wide variation in the reported incidence of coeliac disease in recent decades. We aimed to evaluate the incidence rate of coeliac diagnoses performed in an Italian region, Campania, between 2011 and 2013 and its variation therein.

Methods: All coeliac diagnoses made from 2011 to 2013 and registered within the Campania coeliac disease register (CeliacDB) were identified. Incidence rates were analysed by sex, age and province of residence, with a Poisson model fitted to determine incidence rate ratios.

Results: We found 2049 coeliac disease diagnoses registered in the CeliacDB between 2011 and 2013; 1441 of these patients were female (70.4%) and 1059 were aged less than 19 years (51.7%). The overall incidence of coeliac disease in Campania was 11.8 per 100,000 person-years (95% CI 11.3-12.3) during the study period, with marked variation by age [27.4 per 100,000 person-years (95% CI 25.8-29.1) in children under 19 years of age and 7.3 per 100,000 (95% CI 6.8-7.8) in adults] and sex [16.1 per 100,000 person-years in females (95% CI 15.3-16.9) and 7.2 per 100,000 person-years in males (95% CI 6.6-7.8)]. Coeliac disease incidence was roughly similar in Naples, Salerno, Caserta and Avellino, but about half in Benevento. More than 80% of our study population was diagnosed by the combination of positive antitransglutaminase IgA and Marsh 3. More than half of the patients were symptomatic at the time of coeliac disease diagnosis (39.7% had a classical presentation and 21.1% a non-classical one according to the Oslo definition).

Conclusions: Coeliac disease incidence was roughly similar among Campania provinces, except in Benevento where it was about half, probably due to less awareness of coeliac disease in this area. The incidence of coeliac disease in Campania appears to be lower than that reported by most of the previous literature, suggesting the necessity of new coeliac awareness programmes.

Keywords: Coeliac disease; Italy; clinical presentation; incidence.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Incidence rates of CD per 100,000 person-years according to age group in females and males.
See this image and copyright information in PMC

References

    1. Kang J, Kang A, Green A, et al. Systematic review: Worldwide variation in the frequency of coeliac disease and changes over time. Aliment Pharmacol Ther 2013; 38: 226–245. - PubMed
    1. Ludvigsson JF, Rubio-Tapia A, van Dyke CT, et al. Increasing incidence of celiac disease in a north American population. Am J Gastroenterol 2013; 108: 818–824. - PMC - PubMed
    1. White LE, Merrick VM, Bannerman E, et al. The rising incidence of celiac disease in Scotland. Pediatrics 2013; 132: e924–e931. - PubMed
    1. Riddle MS, Murray JA, Porter CK. The incidence and risk of celiac disease in a healthy US adult population. Am J Gastroenterol 2012; 107: 1248–1255. - PMC - PubMed
    1. Hurley JJ, Lee B, Turner JK, et al. Incidence and presentation of reported coeliac disease in Cardiff and the Vale of Glamorgan: The next 10 years. Eur J Gastroenterol Hepatol 2012; 24: 482–486. - PubMed