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. 2015 Mar;7(3):337-45.
doi: 10.3978/j.issn.2072-1439.2014.10.12.

Impact of body mass index on survival of esophageal squamous carcinoma patients in southern China

Chao Ren  1 , Xiu-Yu Cai  1 , Miao-Zhen Qiu  1 , De-Shen Wang  1 , Feng-Hua Wang  1 , Hui-Yan Luo  1 , Rui-Hua Xu  1
Affiliations

Impact of body mass index on survival of esophageal squamous carcinoma patients in southern China

Chao Ren et al. J Thorac Dis. 2015 Mar.

Abstract

Background: Although high body mass index (BMI) increases risk for developing esophageal adenocarcinoma (EAC), the prognostic influence of BMI is unknown in esophageal squamous carcinoma.

Methods: BMI was calculated using measured height and weight at the first diagnosis and categorized as overweight (25 to 29.9 kg/m(2)), normal (18.5 to 24.9 kg/m(2)) or underweight (<18.5 kg/m(2)). Survival was compared by using the log-rank test on the Kaplan-Meier life table. Multivariate Cox regression analysis was used to evaluate whether BMI was an independent prognostic factor for disease-specific survival (DSS).

Results: Among 1,176 esophageal squamous carcinoma patients, 146 (12.4%) were categorized as overweight, and 277 (23.6%) underweight. More patients in the underweight group had anemia (P=0.001), weight loss (P=0.035) and R1 resection (P<0.001). Less patients in the underweight group received adjuvant chemotherapy (P=0.01). Patients in the overweight group had a higher incidence rate of high blood pressure (P<0.001), diabetes (P<0.001) and coronary artery diseases (P<0.001). Moreover, more patients in the overweight group had a lower TNM stage (P=0.003). In the univariated analysis, high BMI was significantly associated with better DSS (P=0.013).

Conclusions: After adjusting for covariates enrolled for study, high BMI was an independent prognostic factor in weight loss esophageal squamous carcinoma patients.

Keywords: Body mass index (BMI); esophageal squamous carcinoma; overweight; prognostic factor.

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Figures

Figure 1
Figure 1
Survival curves of esophageal squamous carcinoma patients according to body weight change status.
Figure 2
Figure 2
The prognostic impact of BMI on patients with esophageal squamous carcinoma stratified by body weight change: weight stable (A) and weight loss (B). BMI, body mass index.
See this image and copyright information in PMC

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References

    1. Zeng HM, Zheng RS, Zhang SW, et al. Analysis and prediction of esophageal cancer incidence trend in China. Zhonghua Yu Fang Yi Xue Za Zhi 2012;46:593-7. - PubMed
    1. Cao KJ, Fan QY, Liu YL, et al. Cancer incidence and mortality in Guangzhou City from 2000 to 2002. Ai Zheng 2008;27:225-30. - PubMed
    1. Melis M, Weber JM, McLoughlin JM, et al. An elevated body mass index does not reduce survival after esophagectomy for cancer. Ann Surg Oncol 2011;18:824-31. - PMC - PubMed
    1. Yoon HH, Lewis MA, Shi Q, et al. Prognostic impact of body mass index stratified by smoking status in patients with esophageal adenocarcinoma. J Clin Oncol 2011;29:4561-7. - PMC - PubMed
    1. Trivers KF, De Roos AJ, Gammon MD, et al. Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers. Clin Gastroenterol Hepatol 2005;3:225-30. - PubMed