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. 2015:2015:370314.
doi: 10.1155/2015/370314. Epub 2015 Apr 2.

Identification of subgingival periodontal pathogens and association with the severity of periodontitis in patients with chronic kidney diseases: a cross-sectional study

Fidan Bahtiar Ismail  1 , Gener Ismail  2 , Anca Silvia Dumitriu  1 , Catalin Baston  3 , Vlad Berbecar  2 , Roxana Jurubita  2 , Andreea Andronesi  2 , Horia Traian Dumitriu  1 , Ioanel Sinescu  3
Affiliations

Identification of subgingival periodontal pathogens and association with the severity of periodontitis in patients with chronic kidney diseases: a cross-sectional study

Fidan Bahtiar Ismail et al. Biomed Res Int. 2015.

Abstract

Background: The aim of our study was to assess the subgingival profile of 9 periodontal pathogens, by means of real-time PCR, in a group of predialysis chronic kidney disease patients with and without periodontal disease and to identify the risk factors associated with periodontal disease in these patients.

Material and methods: This is a single centre cross-sectional cohort study performed on 70 CKD patients. Patients received a full-mouth periodontal examination and the following parameters were assessed: periodontal pocket depth (PPD), clinical attachment level, bleeding on probing, and plaque index; subgingival biofilm samples were collected from the deepest periodontal pocket of each quadrant and were pooled in one transporting unit. Clinical data were drawn from the medical file of the patients.

Results: T. denticola (P = 0.001), T. forsythia (P < 0.001), and P. micros (P = 0.003) are significantly associated with periodontal disease in CKD subjects but in a multivariate model only age and T. forsythia remain independent risk factors for periodontal disease in patients with CKD.

Conclusions: In our cohort, age and T. forsythia are independently associated with periodontitis in CKD patients. Within the limits of this study, CKD was not significantly associated with a particular subgingival periodontal pathogens profile in periodontitis patients.

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References

    1. USRDS Annual Report, 2012, http://www.usrds.org/2012/pdf/v1_ch1_12.pdf.
    1. Chadban S. J., Briganti E. M., Kerr P. G., et al. Prevalence of kidney damage in Australian adults: the AusDiab kidney study. Journal of the American Society of Nephrology. 2003;14(supplement 2):S131–S138. doi: 10.1097/01.asn.0000070152.11927.4a. - DOI - PubMed
    1. Zhang L., Zhang P., Wang F., et al. Prevalence and factors associated with CKD: a population study from Beijing. American Journal of Kidney Diseases. 2008;51(3):373–384. doi: 10.1053/j.ajkd.2007.11.009. - DOI - PubMed
    1. Fisher M. A., Taylor G. W. A prediction model for chronic kidney disease includes periodontal disease. Journal of Periodontology. 2009;80(1):16–23. doi: 10.1902/jop.2009.080226. - DOI - PMC - PubMed
    1. Ioannidou E., Swede H. Disparities in periodontitis prevalence among chronic kidney disease patients. Journal of Dental Research. 2011;90(6):730–734. doi: 10.1177/0022034511402209. - DOI - PMC - PubMed

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