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Randomized Controlled Trial
. 2015 Sep;39(9):1371-5.
doi: 10.1038/ijo.2015.78. Epub 2015 Apr 30.

High genetic risk individuals benefit less from resistance exercise intervention

Y C Klimentidis  1 , J W Bea  2   3 , T Lohman  4 , P-S Hsieh  1 , S Going  3 , Z Chen  1
Affiliations
Randomized Controlled Trial

High genetic risk individuals benefit less from resistance exercise intervention

Y C Klimentidis et al. Int J Obes (Lond). 2015 Sep.

Abstract

Objectives: Genetic factors have an important role in body mass index (BMI) variation, and also likely have a role in the weight loss and body composition response to physical activity/exercise. With the recent identification of BMI-associated genetic variants, it is possible to investigate the interaction of these genetic factors with exercise on body composition outcomes.

Methods: In a block-randomized clinical trial of resistance exercise among women (n=148), we examined whether the putative effect of exercise on weight and dual-energy x-ray absorptiometry-derived body composition measurements differs according to genetic risk for obesity. Approximately one-half of the sample was randomized to an intervention consisting of a supervised, intensive, resistance exercise program, lasting 1 year. Genetic risk for obesity was defined as a genetic risk score (GRS) comprised of 21 single-nucleotide polymorphisms (SNPs) known to be associated with BMI variation. We examined the interaction of exercise intervention and the GRS on anthropometric and body composition measurements after 1 year of the exercise intervention.

Results: We found statistically significant interactions for body weight (P=0.01), body fat (P=0.01), body fat % (P=0.02) and abdominal fat (P=0.02), whereby the putative effect of exercise is greater among those with a lower level of genetic risk for obesity. No single SNP appears to be a major driver of these interactions.

Conclusions: The weight-loss response to resistance exercise, including changes in body composition, differs according to an individual's genetic risk for obesity.

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Conflict of interest statement

Conflict of Interest Statement: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Change in weight, % fat, and % lean from baseline to year 1 associated with the exercise intervention in three strata of obesity GRS.
See this image and copyright information in PMC

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