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Randomized Controlled Trial
. 2015 Sep;39(9):1371-5.
doi: 10.1038/ijo.2015.78. Epub 2015 Apr 30.

High genetic risk individuals benefit less from resistance exercise intervention

Y C Klimentidis  1 , J W Bea  2   3 , T Lohman  4 , P-S Hsieh  1 , S Going  3 , Z Chen  1
Affiliations
Randomized Controlled Trial

High genetic risk individuals benefit less from resistance exercise intervention

Y C Klimentidis et al. Int J Obes (Lond). 2015 Sep.

Abstract

Objectives: Genetic factors have an important role in body mass index (BMI) variation, and also likely have a role in the weight loss and body composition response to physical activity/exercise. With the recent identification of BMI-associated genetic variants, it is possible to investigate the interaction of these genetic factors with exercise on body composition outcomes.

Methods: In a block-randomized clinical trial of resistance exercise among women (n=148), we examined whether the putative effect of exercise on weight and dual-energy x-ray absorptiometry-derived body composition measurements differs according to genetic risk for obesity. Approximately one-half of the sample was randomized to an intervention consisting of a supervised, intensive, resistance exercise program, lasting 1 year. Genetic risk for obesity was defined as a genetic risk score (GRS) comprised of 21 single-nucleotide polymorphisms (SNPs) known to be associated with BMI variation. We examined the interaction of exercise intervention and the GRS on anthropometric and body composition measurements after 1 year of the exercise intervention.

Results: We found statistically significant interactions for body weight (P=0.01), body fat (P=0.01), body fat % (P=0.02) and abdominal fat (P=0.02), whereby the putative effect of exercise is greater among those with a lower level of genetic risk for obesity. No single SNP appears to be a major driver of these interactions.

Conclusions: The weight-loss response to resistance exercise, including changes in body composition, differs according to an individual's genetic risk for obesity.

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Conflict of interest statement

Conflict of Interest Statement: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Change in weight, % fat, and % lean from baseline to year 1 associated with the exercise intervention in three strata of obesity GRS.
See this image and copyright information in PMC

References

    1. Bea J, Cussler E, Going S, Blew R, Metcalfe L, Lohman T. Resistance Training Predicts Six-Year Body Composition Change in Postmenopausal Women. Med Sci Sport Exerc. 2010;42(7):1286–95. - PMC - PubMed
    1. Teixeira PJ, Going SB, Houtkooper LB, Metcalfe LL, Blew RM, Flint-Wagner HG, et al. Resistance training in postmenopausal women with and without hormone therapy. Med Sci Sports Exerc. 2003;35(4):555–62. - PubMed
    1. Stunkard AJ, Harris JR, Pedersen NL, McClearn GE. N Engl J Med [Internet] Department of Psychiatry, University of Pennsylvania; Philadelphia: 1990. May 24, The body-mass index of twins who have been reared apart. 322(0028-4793 (Print) LA – eng PT – Journal Article PT – Research Support, Non-U.S. Gov’t PT – Research Support, U.S. Gov’t, P.H.S SB – AIM SB – IM):1483–7. - PubMed
    1. Bouchard C, Dionne F, Simoneau J, Boulay M. Genetics of aerobic and anaerobic performances. Exerc Sport Sci Rev. 1992;20:27–58. - PubMed
    1. Bouchard C, Rankinen T. Individual differences in response to regular physical activity. Med Sci Sports Exerc. 2001;33(6 Suppl):S446–51. discussion S452–3. - PubMed

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