Ameloblastoma: a clinical review and trends in management

Andrew C McClary¹, Robert B West², Ashley C McClary³, Jonathan R Pollack², Nancy J Fischbein⁴, Christopher F Holsinger⁵, John Sunwoo⁵, A Dimitrios Colevas⁶, Davud Sirjani⁷

Affiliations

¹ Department of Pathology, Stanford University, 300 Pasteur Drive, Lane 235, Stanford, CA, 94305-5324, USA. amcclary@stanford.edu.
² Department of Pathology, Stanford University, 300 Pasteur Drive, Lane 235, Stanford, CA, 94305-5324, USA.
³ Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
⁴ Department of Radiology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
⁵ Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University, 801 Welch Rd., MC 5739, Stanford, CA, 94305, USA.
⁶ Division of Oncology, Department of Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
⁷ Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University, 801 Welch Rd., MC 5739, Stanford, CA, 94305, USA. dsirjani@ohns.stanford.edu.

PMID: 25926124
DOI: 10.1007/s00405-015-3631-8

Review

Ameloblastoma: a clinical review and trends in management

Andrew C McClary et al. Eur Arch Otorhinolaryngol. 2016 Jul.

. 2016 Jul;273(7):1649-61.

doi: 10.1007/s00405-015-3631-8. Epub 2015 Apr 30.

Authors

Andrew C McClary¹, Robert B West², Ashley C McClary³, Jonathan R Pollack², Nancy J Fischbein⁴, Christopher F Holsinger⁵, John Sunwoo⁵, A Dimitrios Colevas⁶, Davud Sirjani⁷

Affiliations

¹ Department of Pathology, Stanford University, 300 Pasteur Drive, Lane 235, Stanford, CA, 94305-5324, USA. amcclary@stanford.edu.
² Department of Pathology, Stanford University, 300 Pasteur Drive, Lane 235, Stanford, CA, 94305-5324, USA.
³ Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
⁴ Department of Radiology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
⁵ Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University, 801 Welch Rd., MC 5739, Stanford, CA, 94305, USA.
⁶ Division of Oncology, Department of Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
⁷ Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University, 801 Welch Rd., MC 5739, Stanford, CA, 94305, USA. dsirjani@ohns.stanford.edu.

PMID: 25926124
DOI: 10.1007/s00405-015-3631-8

Abstract

Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.

Keywords: Ameloblastoma; BRAF; Clinical review; Genomics; Head and neck surgery; Personalized medicine; SHH.

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References

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Ameloblastoma: a clinical review and trends in management

Affiliations

Ameloblastoma: a clinical review and trends in management

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous