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Review
. 2015 Apr 9:9:2079-88.
doi: 10.2147/DDDT.S78757. eCollection 2015.

Management of severe sepsis: advances, challenges, and current status

Ignacio Martin-Loeches  1 , Mitchell M Levy  2 , Antonio Artigas  3
Affiliations
Review

Management of severe sepsis: advances, challenges, and current status

Ignacio Martin-Loeches et al. Drug Des Devel Ther. .

Abstract

The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies.

Keywords: biomarkers; critical care; guidelines; sepsis; septic shock; surviving sepsis campaign.

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Figures

Figure 1
Figure 1
Fluid administration between 0 and 6 hours. Abbreviations: ProCESS, Protocolized Care for Early Septic Shock; EGDT, Early Goal-Directed Therapy.
Figure 2
Figure 2
Steroids for treatment of infections, sepsis, and septic shock – ups and downs. Abbreviations: SSC, Surviving Sepsis Campaign.
See this image and copyright information in PMC

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