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Review
. 2015 Apr 9:9:2089-100.
doi: 10.2147/DDDT.S79592. eCollection 2015.

Drug delivery strategies to enhance the permeability of the blood-brain barrier for treatment of glioma

Fang Zhang  1 , Chun-Lei Xu  1 , Chun-Mei Liu  1
Affiliations
Review

Drug delivery strategies to enhance the permeability of the blood-brain barrier for treatment of glioma

Fang Zhang et al. Drug Des Devel Ther. .

Abstract

Gliomas are amongst the most insidious and destructive types of brain cancer and are associated with a poor prognosis, frequent recurrences, and extremely high lethality despite combination treatment of surgery, radiotherapy, and chemotherapy. The existence of the blood-brain barrier (BBB) restricts the delivery of therapeutic molecules into the brain and offers the clinical efficacy of many pharmaceuticals that have been demonstrated to be effective for other kinds of tumors. This challenge emphasizes the need to be able to deliver drugs effectively across the BBB to reach the brain parenchyma. Enhancement of the permeability of the BBB and being able to transport drugs across it has been shown to be a promising strategy to improve drug absorption and treatment efficacy. This review highlights the innovative technologies that have been introduced to enhance the permeability of the BBB and to obtain an optimal distribution and concentration of drugs in the brain to treat gliomas, such as nanotechniques, hyperthermia techniques, receptor-mediated transport, cell-penetrating peptides, and cell-mediated delivery.

Keywords: blood–brain barrier; cell-mediated delivery; cell-penetrating peptides; drug delivery, nanotechnology; glioma; hyperthermia; receptor-mediated transport.

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Figures

Figure 1
Figure 1
Representative schematic of several strategies to enhance the permeability of the blood–brain barrier for the delivery of therapeutic agents to the brain parenchyma. Abbreviations: CPP, cell-penetrating peptides; NPs, nanoparticles; RMT, receptor-mediated transport.
See this image and copyright information in PMC

References

    1. Jovčevska I, Kočevar N, Komel R. Glioma and glioblastoma – how much do we (not) know? Mol Clin Oncol. 2013;1:935–941. - PMC - PubMed
    1. Bicker J, Alves G, Fortuna A, Falcão A. Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review. Eur J Pharm Biopharm. 2014;87:409–432. - PubMed
    1. Ni D, Zhang J, Bu W, et al. Dual-targeting upconversion nanoprobes across the blood–brain barrier for magnetic resonance/fluorescence imaging of intracranial glioblastoma. ACS Nano. 2014;8:1231–1242. - PubMed
    1. Shively KM, Langheinrich BW, Keucher T, Cockerill D. Glioblastoma, brain metastases, spine metastases. Oncol Care News. 2012;III:1–8.
    1. Stuplich M, Hadizadeh DR, Kuchelmeister K, et al. Late and prolonged pseudoprogression in glioblastoma after treatment with lomustine and temozolomide. J Clin Oncol. 2012;30:2012–2015. - PubMed

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