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Review
. 2015 Apr 14:6:82.
doi: 10.3389/fneur.2015.00082. eCollection 2015.

Network collapse and cognitive impairment in multiple sclerosis

Menno M Schoonheim  1 , Kim A Meijer  1 , Jeroen J G Geurts  1
Affiliations
Review

Network collapse and cognitive impairment in multiple sclerosis

Menno M Schoonheim et al. Front Neurol. .
No abstract available

Keywords: activation; cognition; connectivity; functional MRI; functional reorganization; multiple sclerosis; networks.

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Figures

Figure 1
Figure 1
A hypothesis of network collapse as a cause for developing cognitive impairment in MS. In early stages of MS, structural damage is low, leaving network efficiency relatively high. As the structural damage accumulates over time, network efficiency levels drop, inducing a network collapse after a critical threshold (indicated by the dotted line) is exceeded. After this, the network is unable to function normally and cognitive impairment develops.
See this image and copyright information in PMC

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