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Comment
. 2014 Nov 18;16(6):467.
doi: 10.1186/s13058-014-0467-x.

A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer

Laoighse Mulrane  1 , William M Gallagher  2 , Darran P O'Connor  3
Affiliations
Comment

A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer

Laoighse Mulrane et al. Breast Cancer Res. .

Abstract

miR-31 is well known as an anti-metastatic microRNA (miRNA) in the context of breast cancer. However, to date the mechanism of regulation of this miRNA has yet to be elucidated. The recent publication by Viré et al. in Molecular Cell demonstrates for the first time that one mechanism of regulation of miR-31 is through the putative oncogene EMSY, whose amplification in breast cancer patients correlates with reduced expression of the miRNA. This regulation is dependent on the DNA-binding transcription factor ETS-1 which recruits EMSY and the histone demethylase KDM5B to the miR-31 promoter, thus repressing its transcription.

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Figures

Figure 1
Figure 1
Proposed mechanism of regulation of miR-31 in breast cancer (adapted from [[7]]). ETS-1 recruits oncogene EMSY and H3K4me3 demethylase KDM5B to the promoter of miR-31, repressing transcription of the pri-miRNA.
See this image and copyright information in PMC

Comment on

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