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Review
. 2015 Apr 28;20(5):7750-71.
doi: 10.3390/molecules20057750.

Anti-trypanosomal activity of nigerian plants and their constituents

Ngozi Justina Nwodo  1 , Akachukwu Ibezim  2 , Fidele Ntie-Kang  3 , Michael Umale Adikwu  4 , Chika John Mbah  5
Affiliations
Review

Anti-trypanosomal activity of nigerian plants and their constituents

Ngozi Justina Nwodo et al. Molecules. .

Abstract

African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally. Nigerian medicinal plants are known to contain a large variety of chemical structures and some of the plant extracts have been screened for antitrypanosomal activity, in the search for potential new drugs against the illness. We surveyed the literatures on plants and plant-derived products with antitrypanosomal activity from Nigerian flora published from 1990 to 2014. About 90 plants were identified, with 54 compounds as potential active agents and presented by plant families in alphabetical order. This review indicates that the Nigerian flora may be suitable as a starting point in searching for new and more efficient trypanocidal molecules.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of compounds 1–8.
Figure 2
Figure 2
Chemical structures of compounds 9 to 15.
Figure 3
Figure 3
Chemical structures of compounds 16 to 21.
Figure 4
Figure 4
Chemical structures of compounds 22–54.
Figure 4
Figure 4
Chemical structures of compounds 22–54.
See this image and copyright information in PMC

References

    1. D’Archivio S., Medina M., Cosson A., Chamond N., Rotureau B., Minoprio P. Genetic engineering of Trypanosoma (Dutonella) vivax and in vitro differentiation under axenic conditions. PLoS Negl. Trop. Dis. 2011;5:e1461. - PMC - PubMed
    1. Joshua R.A., Magaji Y., Kayit Y.S. Isolation of human serum resistant Trypanozoon from cattle in Nigeria. Tropenmedizin Parasitol. 1983;13:201–202. - PubMed
    1. Ayodele O.M., Akinyemi F., Charles D., Kim P., Michael V.T., Susan C.W. A Longitudinal Survey of African Animal Trypanosomiasis in Domestic Cattle on the Jos Plateau, Nigeria: Prevalence, Distribution and Risk Factors. Parasites Vectors. 2013;6:239. doi: 10.1186/1756-3305-6-239. - DOI - PMC - PubMed
    1. Airauhi L., Unuigbe E.I., Airauchi O.D. Human sleeping sickness (SS) in Nigeria: Knowledge, attitude and beliefs in a focus in the Abraka belt, Delta of Nigeria. Afr. J. Clin. Exp. Microbiol. 2001;2:6–9.
    1. Edeghere H., Elhassan E., Ukah J.C.A., Sanda S., Ikenga M., Audu G. The scourge of human African trypanosomiasis in Abraka: possible control strategies. Nig. Soc. Parasitol. Abst. 1998;46:43.

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