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Comment
. 2014 Nov 6;16(6):471.
doi: 10.1186/s13058-014-0471-1.

An unexpected alliance between stress responses to drive oncogenesis

Melissa M Keenan  1   2 , Chien-Kuang Cornelia Ding  3   4 , Jen-Tsan Chi  5   6
Affiliations
Comment

An unexpected alliance between stress responses to drive oncogenesis

Melissa M Keenan et al. Breast Cancer Res. .

Abstract

XBP1 is a well-characterized regulator of the unfolding protein response that is activated in response to unfolded or misfolded proteins or nutrient deprivation. The conventional wisdom is that XBP1 is activated to coordinate the unfolded protein response and promote cellular survival under stresses. A recent study provides intriguing evidence that, in triple-negative breast cancer, XBP1 plays a major role in promoting oncogenesis and cancer stem cell properties. Unexpectedly, XBP1 accomplishes this by recruiting hypoxia-inducible factor 1α and activating oncogenic transcriptional programs. This study reveals a surprising hierarchy and alliance between two stress regulators with distinct transcriptional outputs to promote an aggressive oncogenic state.

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  • XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.
    Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH. Chen X, et al. Nature. 2014 Apr 3;508(7494):103-107. doi: 10.1038/nature13119. Epub 2014 Mar 23. Nature. 2014. PMID: 24670641 Free PMC article.

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