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Comment
. 2014 May 19;16(3):307.
doi: 10.1186/bcr3657.

CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer

Olafur A Stefansson  1   2 , Manel Esteller  3   4   5
Affiliations
Comment

CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer

Olafur A Stefansson et al. Breast Cancer Res. .

Abstract

In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regulates the genomic localization of BAF155 (a SWI/SNF subunit involved in chromatin remodeling) through post-translational methylation at R1064 arginine residues. This modification leads to the relocalization of BAF155-containing SWI/SNF complexes to regions containing genes involved in the Myc oncogenic pathway. The results presented are evidence that these interactions constitute a mechanism by which the BAF155 chromatin remodeling factor contributes to cancer.

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References

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