Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2015;14(10):1489-90.
doi: 10.1080/15384101.2015.1032646.

Pancreatic oncogenic signaling cascades converge at Protein Kinase D1

Geou-Yarh Liou  1 , Michael Leitges, Peter Storz
Affiliations
Editorial

Pancreatic oncogenic signaling cascades converge at Protein Kinase D1

Geou-Yarh Liou et al. Cell Cycle. 2015.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic overview of how PKD1 is involved in regulation of ADM downstream of EGFR and mutant Kras. Activation of wildtype Kras via EGFR or acquisition of an oncogenic Kras mutation (here KrasG12D) both lead to upregulation and activation of PKD1. PKD1 once activated mediates ADM through Notch.
See this image and copyright information in PMC

Comment on

References

    1. Huang H, et al.. Oncogene 2014; 33:532-5; PMID:23334325; http://dx.doi.org/10.1038/onc.2012.619 - DOI - PMC - PubMed
    1. Daniluk J, et al.. J Clin Invest 2012; 122:1519-28; PMID:22406536; http://dx.doi.org/10.1172/JCI59743 - DOI - PMC - PubMed
    1. Ardito CM, et al.. Cancer Cell 2012; 22:304-17; PMID:22975374; http://dx.doi.org/10.1016/j.ccr.2012.07.024 - DOI - PMC - PubMed
    1. Liou GY, et al.. Nat Commun 2015; 6:6200; PMID:25698580; http://dx.doi.org/10.1038/ncomms7200 - DOI - PMC - PubMed
    1. Apelqvist A, et al.. Nature 1999; 400:877-81; PMID:10476967; http://dx.doi.org/10.1038/23716 - DOI - PubMed

Substances

LinkOut - more resources