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Comment
. 2015;14(11):1621-2.
doi: 10.1080/15384101.2015.1032651.

EcSTAT3ic about K63-Linked Ubiquitylation of IKKβ

Andrea C Carrano  1
Affiliations
Comment

EcSTAT3ic about K63-Linked Ubiquitylation of IKKβ

Andrea C Carrano. Cell Cycle. 2015.
No abstract available

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Figures

Figure 1.
Figure 1.
K63-linked ubiquitylation of IKKβ activates STAT3 signaling. IKKβ mutation at K171 associated with multiple myeloma and other cancers leads to increased IKKβ activation, indicated by phosphorylation on 2 serine residues (S177 and S181) and K63-linked polyubiquitylation on K147. IKKβ mutation also constitutively activates STAT3 signaling which likely causes tumorigenisis by maintaining elevated NFκΒ activity. Inhibition of the E2 ubiquitin-conjugating complex UBC13/UEV1A responsible for IKKβ K63-linked ubiquitylation blocks this constitutive STAT3 signaling while not affecting IKKβ kinase activity.
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