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Clinical Trial
. 2015 Apr 30;10(4):e0125298.
doi: 10.1371/journal.pone.0125298. eCollection 2015.

Task type affects location of language-positive cortical regions by repetitive navigated transcranial magnetic stimulation mapping

Theresa Hauck  1 , Noriko Tanigawa  2 , Monika Probst  3 , Afra Wohlschlaeger  3 , Sebastian Ille  1 , Nico Sollmann  1 , Stefanie Maurer  1 , Claus Zimmer  3 , Florian Ringel  1 , Bernhard Meyer  1 , Sandro M Krieg  1
Affiliations
Clinical Trial

Task type affects location of language-positive cortical regions by repetitive navigated transcranial magnetic stimulation mapping

Theresa Hauck et al. PLoS One. .

Abstract

Objectives: Recent repetitive TMS (rTMS) mapping protocols for language mapping revealed deficits of this method, mainly in posterior brain regions. Therefore this study analyzed the impact of different language tasks on the localization of language-positive brain regions and compared their effectiveness, especially with regard to posterior brain regions.

Methods: Nineteen healthy, right-handed subjects performed object naming, pseudoword reading, verb generation, and action naming during rTMS language mapping of the left hemisphere. Synchronically, 5 Hz/10 pulses were applied with a 0 ms delay.

Results: The object naming task evoked the highest error rate (14%), followed by verb generation (13%) and action naming (11%). The latter revealed more errors in posterior than in anterior areas. Pseudoword reading barely generated errors, except for phonological paraphasias.

Conclusions: In general, among the evaluated language tasks, object naming is the most discriminative task to detect language-positive regions via rTMS. However, other tasks might be used for more specific questions.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist. The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

Figures

Fig 1
Fig 1. Outline of the 46 stimulated cortical spots.
Each point was stimulated for three times.
Fig 2
Fig 2. Error rates per stimulation spot during object naming, pseudoword reading, verb generation, and action naming.
Results are presented for all regions (a), for anterior regions (b), and for posterior regions (c).
Fig 3
Fig 3. Overall error rates revealed by language mapping via rTMS.
Distribution of elicited naming errors while performing object naming (a), pseudoword reading (b), verb generation (c), and action naming (d).
Fig 4
Fig 4. Error type (%) differences across task types.
Error rates per error category during object naming, pseudoword reading, verb generation, and action naming shown for all regions, anterior regions, and posterior regions.
See this image and copyright information in PMC

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