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Comment
. 2015 Dec;67(6):932-5.
doi: 10.1111/his.12729. Epub 2015 Jun 19.

Secondary cutaneous involvement by systemic anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma with 6p25.3 rearrangement

Andrew L Feldman  1 , Karen L Grogg  1 , Ryan A Knudson  1 , David J Inwards  2
Affiliations
Comment

Secondary cutaneous involvement by systemic anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma with 6p25.3 rearrangement

Andrew L Feldman et al. Histopathology. 2015 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Secondary cutaneous involvement by systemic ALK-negative ALCL with 6p25.3 rearrangement. A. Low-power photomicrograph of skin lesion. B. Epidermotropic infiltrate of small lymphocytes. C. Sheet-like growth of large cells including “hallmark” cells (inset). D. Epidermotropic component staining for CD3. E. Dermal component staining for CD3. F. Epidermotropic component staining weakly for CD30. G. Epidermotropic component staining strongly for CD30.
Figure 2
Figure 2
Comparative molecular findings in presenting lymph node (1982) and secondary cutaneous involvement (2011). A. Capillary electrophoresis tracings demonstrating clonal peaks for T-cell receptor-β from lymph node. B. Tracings demonstrating identical peaks in subsequent skin biopsy. C. FISH image from lymph node biopsy using breakapart probe showing one intact fusion signal (f) and one split signal (arrows), indicating a 6p25.3 rearrangement. D. FISH image from subsequent skin biopsy, showing same features.
See this image and copyright information in PMC

Comment on

References

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