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Comment
. 2015 May 1;593(9):2115-7.
doi: 10.1113/JP270177.

More than mitochondrial biogenesis: alternative roles of PGC-1α in exercise adaptation

William J Smiles  1 , Donny M Camera
Affiliations
Comment

More than mitochondrial biogenesis: alternative roles of PGC-1α in exercise adaptation

William J Smiles et al. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1
Schematic representation of PGC-1α-mediated stress responses to unfamiliar and chronic contractile activity Preceding detectable increases in mitochondrial biogenesis, PGC-1α enhances glycogen storage via downregulation of glycogenolytic flux, lactate accumulation and glucose oxidation. In addition, unfamiliar contractile stress triggers protein misfolding in the endoplasmic reticulum (ER), which, as a result of unfolded protein response (UPR) signal transduction, may restrain maximal mitochondrial protein synthesis rates. With repeated training, the UPR declines, providing necessary ATP for mitochondrial protein synthesis. Glu, glucose; GLUT1/4, glucose transporters; HK, hexokinase; G6P, glucose 6-phosphate; PFK, phosphofructokinase; PhK, phosphorylase kinase; GPh, glycogen phosphorylase; LDH A/B, lactate dehydrogenase isozymes; PDK4, pyruvate dehydrogenase kinase 4; ATF6α, activating transcription factor 6α.
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