. 2015 Apr 29:2015:bav038.

doi: 10.1093/database/bav038. Print 2015.

NeuroPep: a comprehensive resource of neuropeptides

Yan Wang¹, Mingxia Wang¹, Sanwen Yin¹, Richard Jang², Jian Wang¹, Zhidong Xue³, Tao Xu⁴

Affiliations

¹ Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
² Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
³ Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China zdxue@mail.hust.edu.cn.
⁴ Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China xutao@ibp.ac.cn.

PMID: 25931458
PMCID: PMC4414954
DOI: 10.1093/database/bav038

NeuroPep: a comprehensive resource of neuropeptides

Yan Wang et al. Database (Oxford). 2015.

. 2015 Apr 29:2015:bav038.

doi: 10.1093/database/bav038. Print 2015.

Authors

Yan Wang¹, Mingxia Wang¹, Sanwen Yin¹, Richard Jang², Jian Wang¹, Zhidong Xue³, Tao Xu⁴

Affiliations

¹ Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
² Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
³ Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China zdxue@mail.hust.edu.cn.
⁴ Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China xutao@ibp.ac.cn.

PMID: 25931458
PMCID: PMC4414954
DOI: 10.1093/database/bav038

Abstract

Neuropeptides play a variety of roles in many physiological processes and serve as potential therapeutic targets for the treatment of some nervous-system disorders. In recent years, there has been a tremendous increase in the number of identified neuropeptides. Therefore, we have developed NeuroPep, a comprehensive resource of neuropeptides, which holds 5949 non-redundant neuropeptide entries originating from 493 organisms belonging to 65 neuropeptide families. In NeuroPep, the number of neuropeptides in invertebrates and vertebrates is 3455 and 2406, respectively. It is currently the most complete neuropeptide database. We extracted entries deposited in UniProt, the database (www.neuropeptides.nl) and NeuroPedia, and used text mining methods to retrieve entries from the MEDLINE abstracts and full text articles. All the entries in NeuroPep have been manually checked. 2069 of the 5949 (35%) neuropeptide sequences were collected from the scientific literature. Moreover, NeuroPep contains detailed annotations for each entry, including source organisms, tissue specificity, families, names, post-translational modifications, 3D structures (if available) and literature references. Information derived from these peptide sequences such as amino acid compositions, isoelectric points, molecular weight and other physicochemical properties of peptides are also provided. A quick search feature allows users to search the database with keywords such as sequence, name, family, etc., and an advanced search page helps users to combine queries with logical operators like AND/OR. In addition, user-friendly web tools like browsing, sequence alignment and mapping are also integrated into the NeuroPep database. Database URL: http://isyslab.info/NeuroPep

PubMed Disclaimer

Figures

**Figure 1.**
An overview of the user interface of NeuroPep. (A) The browse output of NPY neuropeptide family. (B) An example of an entry NP03900 of the NPY family. (C) The properties page of the entry NP03900. (D) The structure view page of the entry NP03900.

**Figure 2.**
(A) The neuropeptide frequency distribution based on phyla. (B) The neuropeptide family distribution based on phyla.

**Figure 3.**
(A) The amino acid composition distribution of neuropeptides in NeuroPep database. (B) The amino acid length distribution of neuropeptides in NeuroPep database.

See this image and copyright information in PMC

Cited by

Peptidomic Approaches and Observations in Neurodegenerative Diseases.
Muqaku B, Oeckl P. Muqaku B, et al. Int J Mol Sci. 2022 Jun 30;23(13):7332. doi: 10.3390/ijms23137332. Int J Mol Sci. 2022. PMID: 35806335 Free PMC article. Review.
Changes in the neuropeptide content of Biomphalaria ganglia nervous system following Schistosoma infection.
Wang T, Zhao M, Liang D, Bose U, Kaur S, McManus DP, Cummins SF. Wang T, et al. Parasit Vectors. 2017 Jun 2;10(1):275. doi: 10.1186/s13071-017-2218-1. Parasit Vectors. 2017. PMID: 28578678 Free PMC article.
Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo.
Muir J, Anguiano M, Kim CK. Muir J, et al. Science. 2024 Sep 27;385(6716):eadn6671. doi: 10.1126/science.adn6671. Epub 2024 Sep 27. Science. 2024. PMID: 39325905 Free PMC article. Review.
New techniques, applications and perspectives in neuropeptide research.
DeLaney K, Buchberger AR, Atkinson L, Gründer S, Mousley A, Li L. DeLaney K, et al. J Exp Biol. 2018 Feb 8;221(Pt 3):jeb151167. doi: 10.1242/jeb.151167. J Exp Biol. 2018. PMID: 29439063 Free PMC article. Review.
BIOPEP-UWM Database of Bioactive Peptides: Current Opportunities.
Minkiewicz P, Iwaniak A, Darewicz M. Minkiewicz P, et al. Int J Mol Sci. 2019 Nov 27;20(23):5978. doi: 10.3390/ijms20235978. Int J Mol Sci. 2019. PMID: 31783634 Free PMC article.

See all "Cited by" articles

References

1. Burbach J.P. (2010) Neuropeptides from concept to online database www.neuropeptides.nl. Eur. J. Pharmacol., 626, 27–48. - PubMed
1. Hokfelt T., Broberger C., Xu Z.Q., et al. . (2000) Neuropeptides—an overview. Neuropharmacology, 39, 1337–1356. - PubMed
1. Sobrino Crespo C., Perianes Cachero A., Puebla Jimenez L., et al. . (2014) Peptides and food intake. Front. Endocrinol., 5, 58. - PMC - PubMed
1. Shahjahan M., Kitahashi T., Parhar I.S. (2014) Central pathways integrating metabolism and reproduction in teleosts. Front. Endocrinol., 5, 36. - PMC - PubMed
1. Kormos V., Gaszner B. (2013) Role of neuropeptides in anxiety, stress, and depression: from animals to humans. Neuropeptides, 47, 401–419. - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

NeuroPep: a comprehensive resource of neuropeptides

Affiliations

NeuroPep: a comprehensive resource of neuropeptides

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources