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Comment

. 2015 May 12;112(19):5864-5.

doi: 10.1073/pnas.1505169112. Epub 2015 Apr 30.

Pools and Pols: Mechanism of a mutator phenotype

Christal D Sohl¹, Sreerupa Ray², Joann B Sweasy³

Affiliations

Affiliations

¹ Department of Pharmacology and.
² Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520.
³ Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 joann.sweasy@yale.edu.

PMID: 25931524
PMCID: PMC4434749
DOI: 10.1073/pnas.1505169112

Comment

Pools and Pols: Mechanism of a mutator phenotype

Christal D Sohl et al. Proc Natl Acad Sci U S A. 2015.

. 2015 May 12;112(19):5864-5.

doi: 10.1073/pnas.1505169112. Epub 2015 Apr 30.

Authors

Christal D Sohl¹, Sreerupa Ray², Joann B Sweasy³

Affiliations

¹ Department of Pharmacology and.
² Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520.
³ Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 joann.sweasy@yale.edu.

PMID: 25931524
PMCID: PMC4434749
DOI: 10.1073/pnas.1505169112

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1. — Fig. 1.
Replicative polymerase mutations and dNTP pools can contribute to cancer. Somatic and germ-line mutations in pol ε or pol δ, commonly located in the exonuclease domain, can lead to a loss of proofreading ability. Mutations in the catalytic domain result in deficient substrate discrimination. These mutations initiate signaling pathways that result in increased dNTP pools, further increasing the rate of mutation. This mutator phenotype leads to cancer.

See this image and copyright information in PMC

Comment on

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.
Williams LN, Marjavaara L, Knowels GM, Schultz EM, Fox EJ, Chabes A, Herr AJ. Williams LN, et al. Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2457-66. doi: 10.1073/pnas.1422948112. Epub 2015 Mar 31. Proc Natl Acad Sci U S A. 2015. PMID: 25827226 Free PMC article.
Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity.
Mertz TM, Sharma S, Chabes A, Shcherbakova PV. Mertz TM, et al. Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2467-76. doi: 10.1073/pnas.1422934112. Epub 2015 Mar 31. Proc Natl Acad Sci U S A. 2015. PMID: 25827231 Free PMC article.

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