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Comment
. 2015 May 12;112(19):5864-5.
doi: 10.1073/pnas.1505169112. Epub 2015 Apr 30.

Pools and Pols: Mechanism of a mutator phenotype

Christal D Sohl  1 , Sreerupa Ray  2 , Joann B Sweasy  3
Affiliations
Comment

Pools and Pols: Mechanism of a mutator phenotype

Christal D Sohl et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Replicative polymerase mutations and dNTP pools can contribute to cancer. Somatic and germ-line mutations in pol ε or pol δ, commonly located in the exonuclease domain, can lead to a loss of proofreading ability. Mutations in the catalytic domain result in deficient substrate discrimination. These mutations initiate signaling pathways that result in increased dNTP pools, further increasing the rate of mutation. This mutator phenotype leads to cancer.
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