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Case Reports
. 2015 Apr 21:9:524.
doi: 10.3332/ecancer.2015.524. eCollection 2015.

A rare presentation of primary leiomyosarcoma of ovary in a young woman

J Vijaya Kumar  1 , Anil Khurana  1 , Paramjeet Kaur  1 , Ashok K Chuahan  1 , Sunita Singh  1
Affiliations
Case Reports

A rare presentation of primary leiomyosarcoma of ovary in a young woman

J Vijaya Kumar et al. Ecancermedicalscience. .

Abstract

Primary ovarian leiomyosarcoma is a very rare tumour which is most commonly seen in postmenopausal women. A case is described here involving a 30-year-old female who presented with pain in the abdomen. The patient underwent laparotomy with peritoneal lavage, bilateral salpingo-oophorectomy, and total abdominal hysterectomy. Microscopic and immunohistochemical findings established the diagnosis of primary ovarian leiomyosarcoma. Similar to sarcoma of other tissues, an adjuvant chemotherapy regimen consisting of vincristine, epirubicin, and cyclophosphamide was given for this present case. Six months after treatment completion, the patient is on regular follow-up and disease-free on clinical and radiological examination.

Keywords: chemotherapy; leiomyosarcoma; ovary; radiation therapy; soft tissue sarcoma; surgery.

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Figures

Figure 1a–b.
Figure 1a–b.. Ultrasonography of whole abdomen and pelvis showed a large mass occupying whole of pelvis just superior to fundus of uterus (not arising from the uterus).
Figure 2.
Figure 2.. Chest x-ray PA digital view did not reveal any major abnormalities except for marginal increase of cardiac size in transverse diameter.
Figure 3a–c.
Figure 3a–c.. MRI of pelvis (coronal, sagittal, and transverse view) shows large oval well-defined mass lesion occupying whole of pelvis just superior to fundus of uterus (not arising from the uterus indicated by arrow mark).
Figure 4a–b.
Figure 4a–b.. Cut section of right ovary specimen shows variegated appearance with focal areas of hemorrhage.
Figure 5.
Figure 5.. Photomicrograph showing oval to spindle cells with mild to moderate pleomorphism and high mitotic activity, H & E stain (200X).
Figure 6a.
Figure 6a.. Photomicrograph showing tumour cells showing SMA positivity (200X).
Figure 6b.
Figure 6b.. Photomicrograph showing tumour cells showing vimentin positivity (20X).
Figure 7a–c.
Figure 7a–c.. MRI of abdomen and pelvis (sagittal and transverse view) not showing any abnormalities after the completion of six cycles of adjuvant chemotherapy.
See this image and copyright information in PMC

References

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