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Case Reports
. 2015 Mar 31;9(1):15-8.
doi: 10.3315/jdcr.2015.1191.

Primary cutaneous γ/δ T-cell lymphoma. An atypical case with bone marrow granulomas

Guy Shalom  1 , Ronit Gurion  2 , Daniel Benharroch  3
Affiliations
Case Reports

Primary cutaneous γ/δ T-cell lymphoma. An atypical case with bone marrow granulomas

Guy Shalom et al. J Dermatol Case Rep. .

Abstract

Background: Primary cutaneous γ/δ T-cell lymphoma is a rare variant of peripheral T-cell lymphoma which has been only recently set apart from subcutaneous panniculitis-like T-cell lymphoma and is known for its aggressive nature.

Main observation: We hereby report a case of primary cutaneous γ/δ T-cell lymphoma in a 35-year-old man with bone marrow granulomas, an unexpected feature in this lymphoma. The patient was treated with combination chemotherapy. Partial response was obtained, followed by relapse. Allogeneic stem cell transplantation was then carried out, and full remission was achieved.

Conclusion: Bone marrow granulomas can be an accompanying feature in primary cutaneous γ/δ T-cell lymphoma.

Keywords: bone; cutaneous gamma/delta T-cell lymphoma; lymphoma; peripheral T-cell lymphoma; subcutaneous panniculitis-like T-cell lymphoma; ulcer.

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Figures

Figure 1
Figure 1
Ulcer 2X3 centimeter in diameter, covered with a thin layer of fibrin, left ankle.
Figure 2
Figure 2
Skin biopsy photomicrograph showing evidence of panniculitis. The infiltrate is composed of medium-sized lymphoid cells, some delimiting the lipocytes (H&E, magnification X360).
Figure 3
Figure 3
Skin biopsy, panniculitis. Immunohistochemistry for CD2 (H&E, magnification X 360).
Figure 4
Figure 4
Skin biopsy with panniculitis. A: Perforin-positive tumor cells are evident. B: BetaF1-negative tumor cells are evident. (IHC, using DAB, magnification X360).
See this image and copyright information in PMC

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