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. 2015 Feb 15;8(2):2326-33.
eCollection 2015.

Association between RAD51 polymorphism and breast cancer susceptibility: a meta analysis

Wei Li  1 , Ke-Jia Liu  1 , Jing-Song Song  2 , Rui Song  1 , Zi-Liang Liu  1
Affiliations

Association between RAD51 polymorphism and breast cancer susceptibility: a meta analysis

Wei Li et al. Int J Clin Exp Med. .

Abstract

Background: RAD51 interacting with BRCA1 and BRCA2 could modulate the penetrance of BRCA1/BRCA2 mutations, which may increase susceptibility for breast cancer by inhibiting DNA repair and genome stability. The purpose of this study was to provide refined statistical evidence for the association between RAD51 polymorphism and breast cancer risk.

Design and results: We conducted a meta-analysis of 15 publications with a total of 11,766 cancer cases and 11,227 controls. We summarized the data on the association of RAD51 polymorphism with breast cancer risk and performed subgroup analyses by ethnicity and control source. The pooled ORs based on fixed-effects model did not indicate a modified risk of breast cancer associated with RAD51 polymorphism in the overall population. Nor did we find a significant association in any stratified analysis.

Conclusions: This meta-analysis suggested that RAD51 polymorphism did not appear to represent a significant risk factor for breast cancer.

Keywords: RAD51; breast cancer; polymorphism; susceptibility.

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Figures

Figure 1
Figure 1
Flow diagram of included studies for this meta-analysis.
Figure 2
Figure 2
Forest plot (fixed-effects model) describing the association of the RAD51 G135C polymorphism with risk of breast cancer. The RAD51 G135C polymorphism was not associated with breast cancer under GG vs. CC.
Figure 3
Figure 3
Funnel plot analysis to detect publication bias. Each point represents an individual study for the indicated association (Egger’s test: P = 0.364 for GG vs. GC + CC).
See this image and copyright information in PMC

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