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. 2015 Feb 15;8(2):2411-6.
eCollection 2015.

Ultrasonographic characteristics and BI-RADS-US classification of BRCA1 mutation-associated breast cancer in Guangxi, China

Cheng Li  1 , Junjie Liu  1 , Sida Wang  1 , Yuanyuan Chen  1 , Zhigang Yuan  1 , Jian Zeng  1 , Zhixian Li  1
Affiliations

Ultrasonographic characteristics and BI-RADS-US classification of BRCA1 mutation-associated breast cancer in Guangxi, China

Cheng Li et al. Int J Clin Exp Med. .

Abstract

Objective: To retrospectively analyze and compare the ultrasonographic characteristics and BI-RADS-US classification between patients with BRCA1 mutation-associated breast cancer and those without BRCA1 gene mutation in Guangxi, China.

Methods: The study was performed in 36 lesions from 34 BRCA1 mutation-associated breast cancer patients. A total of 422 lesions from 422 breast cancer patients without BRCA1 mutations served as control group. The comparison of the ultrasonographic features and BI-RADS-US classification between two the groups were reviewed.

Results: More complex inner echo was disclosed in BRCA1 mutation-associated breast cancer patients (x(2) = 4.741, P = 0.029). The BI-RADS classification of BRCA1 mutation-associated breast cancer was lower (U = 6094.0, P = 0.022).

Conclusions: BRCA1 mutation-associated breast cancer frequently displays as microlobulated margin and complex echo. It also shows more benign characteristics in morphology, and the BI-RADS classification is prone to be underestimated.

Keywords: BRCA1 gene; Breast cancer; elastography; mutations; ultrasonography.

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Figures

Figure 1
Figure 1
A: BRCA1 mutation-associated breast cancer tends to be benign lumps in the performance of form, the most common feature is microlobulated; B: Breast cancer without BRCA1 mutation is the more common as Burr or crab-liked.
Figure 2
Figure 2
A: The inside ultrasonic performances of the BRCA1 mutation-associated lesions tend to appear with liquefaction necrosis, and preform as mixed echo; B: The inside ultrasonic performances of the breast cancer without BRCA1 mutation tend to appear with hypoechoic or no liquefaction necrosis.
Figure 3
Figure 3
A: BRCA1 mutation-associated breast cancers are more likely to present with enhancement, unchanged or mixed rear echo; B: Breast cancer without BRCA1 mutation are more likely to present with enhanced, unchanged or mixed rear echo.
See this image and copyright information in PMC

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