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. 2015 Feb 15;8(2):2545-53.
eCollection 2015.

USF-1 genetic polymorphisms confer a high risk of nonalcoholic fatty liver disease in Chinese population

Ying Wang  1 , Bai-Fang Wang  1 , Jing Tong  1 , Bing Chang  1 , Bing-Yuan Wang  1
Affiliations

USF-1 genetic polymorphisms confer a high risk of nonalcoholic fatty liver disease in Chinese population

Ying Wang et al. Int J Clin Exp Med. .

Abstract

Genetic polymorphisms in upstream transcription factor 1 (USF1) were investigated for their links to increased risk of nonalcoholic fatty liver disease (NAFLD) in Chinese population. Between January 2013 and April 2014, 174 patients with NAFLD in the First Affiliated Hospital of China Medical University were selected for this study. A group of 100 healthy subjects were identified as the control group. The MALDI-TOF-MS, a mass spectrometry based technique, was used to detect USF-1 genetic polymorphisms using PCR amplified DNA products. Furthermore, Automatic Chemistry Analyzer (ACA) was used to determine the clinical indicators. Genotypes, allele frequencies and clinical indicators were measured to assess NAFLD risk in relation to the SNPs. USF-1 rs6427573 genetic polymorphisms were associated with an increased risk of NAFLD (AA vs. GG: OR = 3.16, 95% CI = 1.56-6.43, P = 0.001; GA + AA vs. GG: OR = 1.87, 95% CI = 1.13-3.09, P = 0.015; GG + AA vs. AA: OR = 2.96, 95% CI = 1.49-5.88, P = 0.001; G vs. A: OR = 2.10, 95% CI = 1.43-3.09, P < 0.001). Similarly, rs2516839 polymorphisms also conferred a risk for NAFLD (AA vs. GG: OR = 2.49, 95% CI = 1.43-4.34, P = 0.001; GA + AA vs. GG: OR = 1.69, 95% CI = 1.02-2.78, P = 0.041). On the other hand, rs3737787 and rs2774279 showed no statistical significances in the NAFLD group and control group (P > 0.05). Two USF-1 genetic polymorphisms, rs6427573 and rs2516839, may present an increased risk of NAFLD.

Keywords: MALDI-TOF-MS; Upstream transcription factor 1; increased risk; nonalcoholic fatty liver disease; polymorphism; rs2774279; rs3737787; susceptibility.

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Figures

Figure 1
Figure 1
Linkage disequilibrium maps of four SNPs in HapMap CHB population.
Figure 2
Figure 2
Genotyping profiles of USF-1 gene polymorphisms.
See this image and copyright information in PMC

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