Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Feb 15;8(2):2778-83.
eCollection 2015.

Prothrombin complex concentrates utility for warfarin-associated hemorrhage

Secgin Soyuncu  1 , Savas Aslan  1 , Halil Mutlu  1 , Firat Bektas  1
Affiliations

Prothrombin complex concentrates utility for warfarin-associated hemorrhage

Secgin Soyuncu et al. Int J Clin Exp Med. .

Abstract

Introduction: Prothrombin Complex Concentrate (PCC) for reversal of warfarin is the main therapeutic option in cases of life-threatening bleeding. Aim of the study was to investigate for using 4-factor PCC brought to the therapeutic levels of International Normalized Ratio (INR) values in cases of life-threatening bleeding in Emergency Department.

Methods: This retrospective cohort study was performed in a tertiary care university emergency department. Patients with active bleeding who were taking warfarin with INR levels of ≥1.5, and had received 4-factor prothrombin complex concentrate for treatment were included in to study.

Results: A total of 75 patients were included in the study. The median age of the study participants was 68 (minimum 23 to maximum 87) years and 45.3% (n = 34) of them were male. INR levels was normalized all patients who were received 4-factor PCC. Red blood cell (RBC) was transfused in 16 patients (21%) because of the low hemoglobin levels. Mean unite of the RBC packet was 2,75. The lengths of hospital stay of receiving 4-factor PCC rate were determined 4.9 ± 8.7 days. No thrombotic complications or adverse drug reactions were observed after 4-factor PCC administration in any of the patients.

Conclusions: In our study 4-factor PCC was found to be effective and safe in rapidly reversing the effects of warfarin.

Keywords: Prothrombin complex concentrate; hemorrhage; warfarin.

PubMed Disclaimer

Figures

Figure 1
Figure 1
PCC without the patient being given by the previous INR values between subsequent changes in INR values.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Streiff MB. Prothrombin complex concentrates for reversal of vitamin K antagonists: assessing the risks. Thromb Haemost. 2011;106:389–390. - PubMed
    1. Libby EN, Garcia DA. A survey of oral vitamin K use by anticoagulation clinics. Arch Intern Med. 2002;162:1893–1896. - PubMed
    1. Leissinger CA, Blatt PM, Hoots WK, Ewenstein B. Role of Prothrombin complex concentrates in reversing warfarin anticoagulation: a review of the literature. Am J Hematol. 2008;83:137–143. - PubMed
    1. Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuu-nemann HJ American College of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel. Executive summary: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141:7S–47S. - PMC - PubMed
    1. Patanwala AE, Acquisto NM, Erstad BL. Prothrombin complex concentrate for critical bleeding. Ann Pharmacother. 2011;45:990–999. - PubMed

LinkOut - more resources