Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Feb 15;8(2):2934-8.
eCollection 2015.

Correlation of rs1799793 polymorphism in ERCC2 and the clinical response to platinum-based chemotherapy in patients with triple negative breast cancer

Jun Lu  1 , Haitao Zhao  2 , Sha Li  1 , Zhongze Tian  1 , Xianghui Zhu  1 , Hongyi Wang  1 , Hua Fu  1
Affiliations

Correlation of rs1799793 polymorphism in ERCC2 and the clinical response to platinum-based chemotherapy in patients with triple negative breast cancer

Jun Lu et al. Int J Clin Exp Med. .

Abstract

Background: Polymorphisms of DNA repair genes may affect the repair capacity of DNA damages and cause different responses towards chemotherapy. Excision repair cross-complementing group 2 (ERCC2) plays an important role in the nucleotide excision repair.

Objectives: The aim of this study was to investigate the association between ERCC2 single nucleotide polymorphisms (SNPs) and the response to platinum-based chemotherapy among patients with triple negative breast cancer.

Methods: In total, 60 triple negative breast cancer patients treated with platinum-based chemotherapy were studied. The clinical, pathological and treatment data of them were collected. Sequenom's MassARRAY system was used in the detection of the SNPs of ERCC2. Finally, the association between genotypes and different clinical responses among patients was analyzed. All of the patients received a platinum-based chemotherapy for 4 cycles in median and achieved an overall response rate of 66.7%, showing a comparative good response towards platinum-based chemotherapy among triple negative breast cancer. Fifty-three of the 60 patients had got the results of ERCC2 rs1799793 polymorphisms after MassARRAY detection.

Results: The proportion of GG genotype and GA genotype was 81.1% and 18.9% respectively. The response rate of the rs1799793 GG genotype group was 69.8%, while the GA genotype group only had a response rate of 30.0%. It turned out that the GG genotype was associated with better response towards platinum-based chemotherapy (P=0.030).

Conclusions: ERCC2 rs1799793 polymorphism may be associated with the clinical sensitivity of platinum-based chemotherapy and could be a potential predictive biomarker for triple negative breast cancer patients treated with platinum compounds.

Keywords: Excision repair cross-complementing group 2; platinum-based chemotherapy; response; single nucleotide polymorphisms; triple negative breast cancer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bauer KR, Brown M, Cress RD, Parise CA, Caggiano V. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER-2-negative invasive breast cancer, the so-called triple-negative phenotype: a population based study from the California cancer registry. Cancer. 2007;109:1721–1728. - PubMed
    1. Krockenberger M, Engel JB, Häusler S, Dietl J, Honig A. Prolonged clinical benefit from platinum-based chemotherapy in a patient with metastatic triple negative breast cancer. Eur J Gynaecol Oncol. 2009;30:449–451. - PubMed
    1. Bosken CH, Wei Q, Amos CI, Spitz MR. An analysis of DNA repair as a determinant of survival in patients with non small cell lung cancer. J Natl Cancer Inst. 2002;94:1091–1099. - PubMed
    1. Benhamou S, Sarasin A. ERCC 2/XPD gene polymorphisms and lung cancer: a HuGE review. Am J Epidemiol. 2005;161:1–14. - PubMed
    1. Bonn D. How DNA-repair pathways may affect cancer risk. Lancet. 1998;351:42–42. - PubMed

LinkOut - more resources