Dendritic cell interactions with Histoplasma and Paracoccidioides

Abstract

Fungi are among the most common microbes encountered by humans. More than 100, 000 fungal species have been described in the environment to date, however only a few species cause disease in humans. Fungal infections are of particular importance to immunocompromised hosts in whom disease is often more severe, especially in those with impaired cell-mediated immunity such as individuals with HIV infection, hematologic malignancies, or those receiving TNF-α inhibitors. Nevertheless, environmental disturbances through natural processes or as a consequence of deforestation or construction can expose immunologically competent people to a large number of fungal spores resulting in asymptomatic acquisition to life-threatening disease. In recent decades, the significance of the innate immune system and more importantly the role of dendritic cells (DC) have been found to play a fundamental role in the resolution of fungal infections, such as in dimorphic fungi like Histoplasma and Paracoccidioides. In this review article the general role of DCs will be illustrated as the bridge between the innate and adaptive immune systems, as well as their specific interactions with these 2 dimorphic fungi.

Keywords: DC, dentritic cells(s); HKHC, heat-killed H.capsulatum; Histoplasma; PAMP, pathogen-associated molecular patterns; PCM, paracoccidioidomycosis; PRR, pattern recognition receptors; Paracoccidioides; TLR, toll-like receptor; dendritic cell; immunoresponse.