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Review
. 2015 Nov;29(6):351-7.
doi: 10.1016/j.blre.2015.04.001. Epub 2015 Apr 19.

From evidence to clinical practice in blood and marrow transplantation

Nandita Khera  1
Affiliations
Review

From evidence to clinical practice in blood and marrow transplantation

Nandita Khera. Blood Rev. 2015 Nov.

Abstract

Clinical practice in the field of blood and marrow transplantation (BMT) has evolved over time, as a result of thousands of basic and clinical research studies. While it appears that scientific discovery and adaptive clinical research may be well integrated in case of BMT, there is lack of sufficient literature to definitively understand the process of translation of evidence to practice and if it may be selective . In this review, examples from BMT and other areas of medicine are used to highlight the state of and potential barriers to evidence uptake. Strategies to help improve knowledge transfer are discussed and the role of existing framework provided by the Center for International Blood and Marrow Transplant Registry (CIBMTR) to monitor uptake and BMT Clinical Trials Network (BMT CTN) to enhance translation of evidence into practice is highlighted.

Keywords: Blood and marrow transplantation; Clinical trials; Dissemination and implementation research; Evidence uptake; Practice patterns.

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Figure 1
Phases of translational research.
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References

    1. Green LW, Glasgow RE. Evaluating the Relevance, Generalization, and Applicability of Research: Issues in External Validation and Translation Methodology. Evaluation & the Health Professions. 2006;29(1):126–153. - PubMed
    1. Majhail N. [February 27, 2015];CIBMTR Slides and Reports. http://www.cibmtr.org/ReferenceCenter/SlidesReports/Documents/CIBMTR_Cen....
    1. Naylor CD. Grey zones of clinical practice: some limits to evidence-based medicine. The Lancet. 1995;345(8953):840–842. - PubMed
    1. Elting LS, Cooksley C, Bekele BN, Frumovitz M, Avritscher EB, Sun C, et al. Generalizability of cancer clinical trial results: prognostic differences between participants and nonparticipants. Cancer. 2006;106(11):2452–8. - PubMed
    1. van de Water W, Kiderlen M, Bastiaannet E, Siesling S, Westendorp RGJ, van de Velde CJH, et al. External Validity of a Trial Comprised of Elderly Patients With Hormone Receptor–Positive Breast Cancer. J Natl Cancer Inst. 2014;106(4) - PubMed

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