Regulation of body fat mass by the gut microbiota: Possible mediation by the brain

Erik Schéle¹, Louise Grahnemo², Fredrik Anesten¹, Anna Hallén³, Fredrik Bäckhed⁴, John-Olov Jansson⁵

Affiliations

¹ Institute of Neuroscience and Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden.
² The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden.
³ The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
⁴ The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark. Electronic address: Fredrik.Backhed@wlab.gu.se.
⁵ Institute of Neuroscience and Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden. Electronic address: john-olov.jansson@medic.gu.se.

PMID: 25934163
DOI: 10.1016/j.peptides.2015.03.027

Review

Regulation of body fat mass by the gut microbiota: Possible mediation by the brain

Erik Schéle et al. Peptides. 2016 Mar.

. 2016 Mar:77:54-9.

doi: 10.1016/j.peptides.2015.03.027. Epub 2015 Apr 28.

Authors

Erik Schéle¹, Louise Grahnemo², Fredrik Anesten¹, Anna Hallén³, Fredrik Bäckhed⁴, John-Olov Jansson⁵

Affiliations

¹ Institute of Neuroscience and Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden.
² The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden.
³ The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
⁴ The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark. Electronic address: Fredrik.Backhed@wlab.gu.se.
⁵ Institute of Neuroscience and Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden. Electronic address: john-olov.jansson@medic.gu.se.

PMID: 25934163
DOI: 10.1016/j.peptides.2015.03.027

Abstract

New insight suggests gut microbiota as a component in energy balance. However, the underlying mechanisms by which gut microbiota can impact metabolic regulation is unclear. A recent study from our lab shows, for the first time, a link between gut microbiota and energy balance circuitries in the hypothalamus and brainstem. In this article we will review this study further.

Keywords: BDNF; GLP-1; Gut microbiota; Obesity.

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Regulation of body fat mass by the gut microbiota: Possible mediation by the brain

Affiliations

Regulation of body fat mass by the gut microbiota: Possible mediation by the brain

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Abstract

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