[Renal late effects in patients treated for cancer in childhood]

Abstract

Impaired renal function may occur following multimodal treatment of cancer in childhood. Renal late effects caused by chemotherapy, renal surgery and/or radiotherapy are now well described; but little is known about their prevalence and time of development. Herein, we provide a synthesis of the different renal complications that may occur with their physiopathology in relation with specific treatment exposures. This review summarized the literature that supported the recommendations issued by the long-term follow-up group of the "Société française des cancers de l'enfant (SFCE)" for childhood cancer survivors at risk for nephrotoxicity (www.sfce.org ; www.soc-nephrologie.org/SNP/index.htm). We developed these monitoring elements and the lifestyle recommendations for all asymptomatic survivors.

Keywords: Chimiothérapie néphrotoxique; Dysfonction tubulaire et glomérulaire; HTA; Hypertension; Insuffisance rénale; Nephrectomy; Nephrotoxic chemotherapy; Néphrectomie; Radiothérapie rénale; Renal insufficiency; Renal radiotherapy; Tubular and glomerular dysfunction.