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Review
. 2015 Jun;25(6):317-9.
doi: 10.1016/j.tcb.2015.03.005. Epub 2015 Apr 27.

Are renal ciliopathies (replication) stressed out?

Gisela G Slaats  1 , Rachel H Giles  2
Affiliations
Review

Are renal ciliopathies (replication) stressed out?

Gisela G Slaats et al. Trends Cell Biol. 2015 Jun.

Abstract

Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunction, causes NPHP.

Keywords: DNA damage; cell cycle; cilia; cyclin-dependent kinase; fibrosis; kidney cysts; replication stress.

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