Peptides at the blood brain barrier: Knowing me knowing you

Thomas P Davis¹, Thomas J Abbruscato², Richard D Egleton³

Affiliations

¹ The Davis Lab, Department of Medical Pharmacology, University of Arizona, Tucson, AZ 85724-5050. Electronic address: davistp@email.arizona.edu.
² Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106.
³ Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25755.

PMID: 25937599
PMCID: PMC4627938
DOI: 10.1016/j.peptides.2015.04.020

Review

Peptides at the blood brain barrier: Knowing me knowing you

Thomas P Davis et al. Peptides. 2015 Oct.

. 2015 Oct:72:50-6.

doi: 10.1016/j.peptides.2015.04.020. Epub 2015 Apr 30.

Authors

Thomas P Davis¹, Thomas J Abbruscato², Richard D Egleton³

Affiliations

¹ The Davis Lab, Department of Medical Pharmacology, University of Arizona, Tucson, AZ 85724-5050. Electronic address: davistp@email.arizona.edu.
² Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106.
³ Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25755.

PMID: 25937599
PMCID: PMC4627938
DOI: 10.1016/j.peptides.2015.04.020

Abstract

When the Davis Lab was first asked to contribute to this special edition of Peptides to celebrate the career and influence of Abba Kastin on peptide research, it felt like a daunting task. It is difficult to really understand and appreciate the influence that Abba has had, not only on a generation of peptide researchers, but also on the field of blood brain barrier (BBB) research, unless you lived it as we did. When we look back at our careers and those of our former students, one can truly see that several of Abba's papers played an influential role in the development of our personal research programs.

Keywords: Blood brain barrier; Drug delivery; Neuropeptides; P-glycoprotein; Tight junction proteins; Transporter proteins.

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References

1. Abbruscato TJ, Davis TP. Hypoxia / aglycemia causes rapid decrease in protein expression of E-cadherin. Brain Research. 1999;842:277–286. - PubMed
1. Abbruscato TJ, Davis TP. Rapid hypoxia / aglycemia compromises in vitro blood-brain barrier integrity. J. Pharmacol. Exp. Ther. 1999;289:668–675. - PubMed
1. Abbruscato TJ, Davis TP. Combination of hypoxia/aglycemia compromises in vitro blood-brain barrier integrity. The Journal of pharmacology and experimental therapeutics. 1999a;289:668–675. - PubMed
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1. Abbruscato TJ, Thomas SA, Hruby VJ, Davis TP. Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist, CTAP: comparison with morphine. The Journal of pharmacology and experimental therapeutics. 1997a;280:402–409. - PubMed

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Peptides at the blood brain barrier: Knowing me knowing you

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Peptides at the blood brain barrier: Knowing me knowing you

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