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. 2015 Jun 3;137(21):6746-9.
doi: 10.1021/jacs.5b03760. Epub 2015 May 18.

Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective Hydroboration of α-Arylenamides

Naifu Hu  1 , Guoqing Zhao  1 , Yuanyuan Zhang  1 , Xiangqian Liu  1 , Guangyu Li  1 , Wenjun Tang  1
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Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective Hydroboration of α-Arylenamides

Naifu Hu et al. J Am Chem Soc. .

Abstract

The rhodium-catalyzed asymmetric hydroboration of α-arylenamides with BI-DIME as the chiral ligand and (Bpin)2 as the reagent yields for the first time a series of α-amino tertiary boronic esters in good yields and excellent enantioselectivities (up to 99% ee).

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