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Review
. 2015 Jul;44(5):277-89.
doi: 10.1007/s00249-015-1025-x. Epub 2015 May 5.

Mechanisms of transfer of bioactive molecules through the cell membrane by electroporation

Mindaugas S Venslauskas  1 , Saulius Šatkauskas
Affiliations
Review

Mechanisms of transfer of bioactive molecules through the cell membrane by electroporation

Mindaugas S Venslauskas et al. Eur Biophys J. 2015 Jul.

Abstract

A short review of biophysical mechanisms for electrotransfer of bioactive molecules through the cell membrane by using electroporation is presented. The concept of transient hydrophilic aqueous pores and membrane electroporation mechanisms of single cells and cells in suspension models are analyzed. Alongside the theoretical approach, some peculiarities of drug and gene electrotransfer into cells and applications in clinical trials are discussed.

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