Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jul;44(5):277-89.
doi: 10.1007/s00249-015-1025-x. Epub 2015 May 5.

Mechanisms of transfer of bioactive molecules through the cell membrane by electroporation

Mindaugas S Venslauskas  1 , Saulius Šatkauskas
Affiliations
Review

Mechanisms of transfer of bioactive molecules through the cell membrane by electroporation

Mindaugas S Venslauskas et al. Eur Biophys J. 2015 Jul.

Abstract

A short review of biophysical mechanisms for electrotransfer of bioactive molecules through the cell membrane by using electroporation is presented. The concept of transient hydrophilic aqueous pores and membrane electroporation mechanisms of single cells and cells in suspension models are analyzed. Alongside the theoretical approach, some peculiarities of drug and gene electrotransfer into cells and applications in clinical trials are discussed.

PubMed Disclaimer

References

    1. Biophys J. 1992 Nov;63(5):1320-7 - PubMed
    1. Melanoma Res. 2000 Aug;10(4):381-5 - PubMed
    1. Biophys J. 2005 Mar;88(3):2206-23 - PubMed
    1. J Am Acad Dermatol. 1996 Jan;34(1):82-6 - PubMed
    1. Bioelectrochemistry. 2008 Nov;74(1):38-46 - PubMed

Publication types

Substances

LinkOut - more resources