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. 2015 Jul;58(7):1626-36.
doi: 10.1007/s00125-015-3602-z. Epub 2015 May 5.

Higher glucose, insulin and insulin resistance (HOMA-IR) in childhood predict adverse cardiovascular risk in early adulthood: the Pune Children's Study

Chittaranjan S Yajnik  1 , Prachi A Katre, Suyog M Joshi, Kalyanaraman Kumaran, Dattatray S Bhat, Himangi G Lubree, Nilam Memane, Arun S Kinare, Anand N Pandit, Sheila A Bhave, Ashish Bavdekar, Caroline H D Fall
Affiliations

Higher glucose, insulin and insulin resistance (HOMA-IR) in childhood predict adverse cardiovascular risk in early adulthood: the Pune Children's Study

Chittaranjan S Yajnik et al. Diabetologia. 2015 Jul.

Abstract

Aims/hypothesis: The Pune Children's Study aimed to test whether glucose and insulin measurements in childhood predict cardiovascular risk factors in young adulthood.

Methods: We followed up 357 participants (75% follow-up) at 21 years of age who had undergone detailed measurements at 8 years of age (glucose, insulin, HOMA-IR and other indices). Oral glucose tolerance, anthropometry, plasma lipids, BP, carotid intima-media thickness (IMT) and arterial pulse wave velocity (PWV) were measured at 21 years.

Results: Higher fasting glucose, insulin and HOMA-IR at 8 years predicted higher glucose, insulin, HOMA-IR, BP, lipids and IMT at 21 years. A 1 SD change in 8 year variables was associated with a 0.10-0.27 SD change at 21 years independently of obesity/adiposity at 8 years of age. A greater rise in glucose-insulin variables between 8 and 21 years was associated with higher cardiovascular risk factors, including PWV. Participants whose HOMA-IR measurement remained in the highest quartile (n = 31) had a more adverse cardiovascular risk profile compared with those whose HOMA-IR measurement remained in the lowest quartile (n = 28).

Conclusions/interpretation: Prepubertal glucose-insulin metabolism is associated with adult cardiovascular risk and markers of atherosclerosis. Our results support interventions to improve glucose-insulin metabolism in childhood to reduce cardiovascular risk in later life.

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Figures

Fig. 1
Fig. 1
Flow diagram showing enrolment and follow-up in the Pune Children’s Study
See this image and copyright information in PMC

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