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Comment
. 2015 May 4;212(5):599-600.
doi: 10.1084/jem.2125insight3.

T cell development runs marrow deep

Juan Carlos Zúñiga-Pflücker  1
Affiliations
Comment

T cell development runs marrow deep

Juan Carlos Zúñiga-Pflücker. J Exp Med. .
No abstract available

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Insight from Juan Carlos Zúñiga-Pflücker
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Model of osteocalcin-positive cell control of T lymphopoeisis. Osteocalcin-positive osetoblasts and osteocytes (and, potentially, stromal cells in the thymus) express the Notch ligand DLL4, which binds to Notch receptors on CLPs. The presence of osteocalcin-positive mature osteolineage cells is necessary for adequate production of T-cell component CLPs and their expression of CCR7 and PSGL1.
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References

    1. Yu, V.W.C., et al. . 2015. J. Exp. Med. 10.1084/jem.20141843. - DOI

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