A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia

Y Gocho^{1

2}, N Kiyokawa¹, H Ichikawa³, K Nakabayashi⁴, T Osumi⁵, T Ishibashi^{1

6}, H Ueno¹, K Terada^{1

7}, K Oboki⁸, H Sakamoto³, Y Shioda⁵, M Imai⁹, Y Noguchi⁷, Y Arakawa¹⁰, Y Kojima¹¹, D Toyama¹², K Hata⁴, T Yoshida³, K Matsumoto¹³, M Kato¹⁴, T Fukushima¹⁵, K Koh¹⁰, A Manabe¹⁶, A Ohara¹¹; Tokyo Children’s Cancer Study Group

Affiliations

¹ Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.
² Department of Pediatrics, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
³ Division of Genetics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.
⁴ Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.
⁵ Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
⁶ Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
⁷ Department of Pediatrics, Japanese Red Cross Narita Hospital, Narita, Chiba, Japan.
⁸ Department of Molecular Medical Research, Tokyo Metropolitan Institute of Medical Science Setagaya-ku, Tokyo, Japan.
⁹ Department of Pediatrics, Japanese Red Cross Musashino Hospital, Musashino, Tokyo, Japan.
¹⁰ Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
¹¹ Department of Pediatrics, Toho University Omori Medical Center, Ota-ku, Tokyo, Japan.
¹² Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan.
¹³ Department of Allergy and Immunology, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.
¹⁴ Department of Pediatrics, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
¹⁵ Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
¹⁶ Department of Pediatrics, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan.

PMID: 25943178
DOI: 10.1038/leu.2015.111

A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia

Y Gocho et al. Leukemia. 2015 Dec.

. 2015 Dec;29(12):2445-8.

doi: 10.1038/leu.2015.111. Epub 2015 May 6.

Authors

Affiliations

¹ Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.
² Department of Pediatrics, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
³ Division of Genetics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.
⁴ Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.
⁵ Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
⁶ Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
⁷ Department of Pediatrics, Japanese Red Cross Narita Hospital, Narita, Chiba, Japan.
⁸ Department of Molecular Medical Research, Tokyo Metropolitan Institute of Medical Science Setagaya-ku, Tokyo, Japan.
⁹ Department of Pediatrics, Japanese Red Cross Musashino Hospital, Musashino, Tokyo, Japan.
¹⁰ Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
¹¹ Department of Pediatrics, Toho University Omori Medical Center, Ota-ku, Tokyo, Japan.
¹² Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan.
¹³ Department of Allergy and Immunology, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.
¹⁴ Department of Pediatrics, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
¹⁵ Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
¹⁶ Department of Pediatrics, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan.

PMID: 25943178
DOI: 10.1038/leu.2015.111

No abstract available

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References

1. Nature. 2011 Mar 10;471(7337):189-95 - PubMed
1. Nat Struct Mol Biol. 2013 Sep;20(9):1040-6 - PubMed
1. Leukemia. 2014 Apr;28(4):977-9 - PubMed
1. Leukemia. 2008 Apr;22(4):723-9 - PubMed
1. Crit Rev Eukaryot Gene Expr. 2001;11(4):279-97 - PubMed

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A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia

Affiliations

A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia

Authors

Affiliations

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Miscellaneous