Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec;5(4):365-73.
doi: 10.1016/j.jegh.2015.04.002. Epub 2015 May 2.

First and second line drug resistance among treatment naïve pulmonary tuberculosis patients in a district under Revised National Tuberculosis Control Programme (RNTCP) in New Delhi

Vithal Prasad Myneedu  1 , Ritu Singhal  2 , Khalid Umer Khayyam  3 , Prem Prakash Sharma  4 , Manpreet Bhalla  5 , Digamber Behera  6 , Rohit Sarin  7
Affiliations

First and second line drug resistance among treatment naïve pulmonary tuberculosis patients in a district under Revised National Tuberculosis Control Programme (RNTCP) in New Delhi

Vithal Prasad Myneedu et al. J Epidemiol Glob Health. 2015 Dec.

Abstract

There is limited information of level of drug resistance to first-line and second line anti-tuberculosis agents in treatment naïve pulmonary tuberculosis (PTB) patients from the Indian region. Therefore, the present prospective study was conducted to determine the antimicrobial susceptibility to first-line and second line anti-TB drug resistance in such patients. Sputum samples from consecutive treatment naïve PTB cases registered in Lala Ram Sarup (LRS) district, under RNTCP containing 12 Directly Observed Treatment Centre's (DOTS), were enrolled using cluster sampling technology. A total of 453 samples were received from July 2011 to June 2012. All samples were cultured on solid medium followed by drug susceptibility to first and second line anti-tubercular drugs as per RNTCP guidelines. Primary multi-drug resistance (MDR) was found to be 18/453; (4.0%). Extensively drug resistance (XDR) was found in one strain (0.2%), which was found to be resistant to other antibiotics. Data of drug resistant tuberculosis among treatment naïve TB patients are lacking in India. The presence of XDR-TB and high MDR-TB in small population studied, calls for conducting systematic multi-centric surveillance across the country.

Keywords: Antibiotic; Extensively drug resistance; Multi-drug resistance; Primary; Pulmonary.

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

Fig. 1
Fig. 1
Age and sex distribution of the population enrolled.
Fig. 2
Fig. 2
Distribution of risk factors in the tuberculosis patients.
Fig. 3
Fig. 3
Common clinical symptoms found in newly diagnosed tuberculosis patients.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Dooley SW, Jarvis WR, Martone WJ, Snider D., Jr Multidrug-resistant tuberculosis. Ann Intern Med. 1992;117:257–9. - PubMed
    1. World Health Organization . Global Tuberculosis Report, Geneva, Switzerland, WHO Report 2013. Geneva, Switzerland: WHO/HTM/TB; 2013.
    1. Shah NS, Wright A, Bai GH, Barerra L, Boulahbal F. Worldwide emergence of extensively drug-resistant tuberculosis. Emerg Infect Dis. 2014;13:30–7. - PMC - PubMed
    1. McGrath M, Pittius Gey van NC, Van Helden PD, Warren RM, Warner DF. Mutation rate and the emergence of drug resistance in Mycobacterium tuberculosis. J Antimicrob Chemother. 2014;69:292–302. doi: 10.1093/jac/dkt364. - DOI - PubMed
    1. Sharma SK, Kaushik G, Jha B. Prevalence of multi-drug resistant tuberculosis among newly diagnosed cases of sputum positive pulmonary tuberculosis. Indian J Med Res. 2011;133:308–11. - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources