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. 2015 Nov;68(11):703-6.
doi: 10.1038/ja.2015.55. Epub 2015 May 6.

Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01

Yongqi Tian  1   2 , Xiaochu Qin  3 , Xiuping Lin  1 , Kumaravel Kaliyaperumal  1 , Xuefeng Zhou  1 , Juan Liu  1 , Zhiran Ju  1 , Zhengchao Tu  3 , Yonghong Liu  1
Affiliations

Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01

Yongqi Tian et al. J Antibiot (Tokyo). 2015 Nov.

Abstract

A new xanthone named sydoxanthone C (1) and a new alkaloid named acremolin B (2), together with 10 known compounds (3-12) were isolated from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of compounds (1-12) were determined by the extensive 1D, 2D-NMR, High resolution mass spectra (HRESIMS) data. Compounds 7, 8, 11 and 12 showed significant selective cytotoxicities against HeLa, DU145 and U937 cell lines. In addition, compounds 7, 8 and 11 also exhibited COX-2 inhibitory activities with the prominent IC50 values of 2.4, 7.1 and 10.6 μM, respectively.

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References

    1. Nat Prod Rep. 2011 Feb;28(2):290-344 - PubMed
    1. Chem Pharm Bull (Tokyo). 2007 Feb;55(2):304-7 - PubMed
    1. J Antibiot (Tokyo). 2011 Jun;64(6):465-7 - PubMed
    1. Org Lett. 2013 May 17;15(10):2370-3 - PubMed
    1. Nat Prod Rep. 2014 Jan 17;31(2):160-258 - PubMed

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