Sialic Acid Hydroxamate: A Potential Antioxidant and Inhibitor of Metal-Induced β-Amyloid Aggregates

Abstract

Current methods for Alzheimer's treatment require a three-component system: metal chelators, antioxidants, and amyloid β (Aβ)-peptide-binding scaffolds. We report sialic acid (Sia) hydroxamate as a potential radical scavenger and metal chelator to inhibit Aβ aggregation. A cell viability assay revealed that Sia hydroxamate can protect HeLa and glioblastoma (LN229) cells from oxidative damage induced by the Fenton reaction. Sedimentation and turbidity assays showed profound protection of neuroblastoma SH-SY5Y cells from metal-induced Aβ aggregation and neural toxicity.

Keywords: Alzheimer's disease; amyloid beta-peptides; antioxidant; metal chelator; sialic acid.