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Randomized Controlled Trial
. 2015 Jan 27;7(4):399-404.
doi: 10.5539/gjhs.v7n4p399.

Lidocaine-Prilocaine Cream as Analgesia for IUD Insertion: A Prospective, Randomized, Controlled, Triple Blinded Study

Samira Tavakolian, Mahbobeh Ahmadi Doulabi, Alireza Akbarzade Baghban, Alireza Mortazavi, Maryam Ghorbani  1
Affiliations
Randomized Controlled Trial

Lidocaine-Prilocaine Cream as Analgesia for IUD Insertion: A Prospective, Randomized, Controlled, Triple Blinded Study

Samira Tavakolian et al. Glob J Health Sci. .

Abstract

Introduction: Copper IUD is a long term and reversible contraception which equals tubal ligation in terms of sterilization. One of the barriers to using this contraception method is the fear and the pain associated with its insertion. Eutectic mixture of local anesthetics (EMLA) 5% is a local anesthetic that contains 25 mg lidocaine and 25 mg of prilocaine per gram. Application of topical analgesic cream to the cervix for laser surgery, hysteroscopy and hysterosalpingography is known Aims: this study aimed to determine the effect of EMLA on IUD insertion pain.

Methods: This triple blind clinical trial was conducted on 92 women in a clinic in Hamedan in 2012. After applying the cream on the cervix, pain in three steps, after using Tenaculum, after inserting hystrometr and after inserting IUD and removing IUD insertion tube were assessed with visual analog scale and were compared in EMLA group and placebo group Statistical analysis used to determine and compare the pain of independent t tests, Mann-Whitney U test and repeated measures analysis of variance and chi-square tests to determine the homogeneity of variables and Fisher's exact test was used.

Results: Insertion hystrometr was determined as the most painful IUD insertion. The mean pain at step 2 (inserting hystrometr) was (3.11±2.53) in EMLA group, (5.23±2.31) in placebo group. EMLA cream significantly reduced the pain after using tenaculum (P<0.001), pain inserting Hystrometr (P< 0.001) and pain at IUD insertion and removing insertion tube (P< 0.001) CONCLUSIONS: Topical Application of EMLA 5% cream as a topical anesthetic on the cervix before insertion IUD reduced the pain during this procedure.

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Figures

Figure 1
Figure 1
Stratified random sampling was used to allocate the samples in blocks of 4. Most probable confounding variables were controlled, such as age, number and type of delivery. So, people in each block were matched for age, type and number of deliveries
Figure 2
Figure 2
The severity of pain was measured in 3 stages
See this image and copyright information in PMC

References

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