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. 2015;63(7):504-11.
doi: 10.1248/cpb.c15-00081. Epub 2015 May 1.

Quantitative analysis of marker compounds in Angelica gigas, Angelica sinensis, and Angelica acutiloba by HPLC/DAD

Su Yang Jeong  1 , Hye Mi Kim, Kyu Ha Lee, Kyu Yeob Kim, Dae Sun Huang, Jong Hwan Kim, Rack Seon Seong
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Free article

Quantitative analysis of marker compounds in Angelica gigas, Angelica sinensis, and Angelica acutiloba by HPLC/DAD

Su Yang Jeong et al. Chem Pharm Bull (Tokyo). 2015.
Free article

Abstract

Although Danggui is the root of Angelica gigas NAKAI in the Korean Pharmacopoeia, it is determined that Danggui is also the root of Angelica sinensis (OLIV.) DIELS in China and Hong Kong, as well as the root of Angelica acutiloba KITAGAWA in Japan. Accordingly, we tried to develop an identification method using the main compounds in A. gigas, A. sinensis, and A. acutiloba through HPLC/diode-array detector (DAD). This method was fully validated for linearity, accuracy, precision, recovery, and robustness. Multivariate analysis was also implemented after pattern analysis and monitoring. As a result, each compound pattern of A. gigas, A. sinensis, and A. acutiloba was identified, making it possible to distinguish them from each other.

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