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. 2015 Apr;23(2):407-10.
doi: 10.7534/j.issn.1009-2137.2015.02.021.

[Expression Changes of β-catenin and P-GSK-3β in Patients with Mantle Cell Lymphoma]

[Article in Chinese]
Jin-Shui He  1 , Yi-Qun Huang  2 , Jian-Ming Weng  3 , Li-Yun Xiao  1 , Kai-Zhi Weng  1 , Xu-Dong Ma  4
Affiliations

[Expression Changes of β-catenin and P-GSK-3β in Patients with Mantle Cell Lymphoma]

[Article in Chinese]
Jin-Shui He et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Apr.

Abstract

Objective: This study was purposed to detect the expressions of β-catenin and P-GSK-3 β in Wnt signaling pathway of patients with mantle cell lymphoma(MCL), and investigate its relationship with the pathogenesis of MCL.

Methods: The expression levels of β -catenin protein and P-GSK-3 protein in mantle cell lymphoma and hyperplastic lymphadenitis were detected by using anti-β-catenin, P-GSK-3β polyclonal antibody and S-P staining technique.

Results: The abnormal expression of β-catenin protein(73.33%) in mantle cell lymphoma group was significantly higher than that (6.7%) in reactive lymph node hyperplasia group (P<0.05); and the positive rate of P-GSK-3 β(66.67%) in mantle cell lymphoma group was significantly higher than that (16.67%) in reactive hyperplasia of lymph node group (P<0.05). Spearman correlation analysis showed that there was obvious positive correlation (R=0.852, P<0.01).

Conclusion: The abnormal high expressions of β-catenin and P-GSK-3 β protein have been confirmed to appeare in mantle cell lymphoma.

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