Review
doi: 10.4103/0970-9185.155140.
Perioperative chlorhexidine allergy: Is it serious?
Affiliations
- PMID: 25948892
- PMCID: PMC4411825
- DOI: 10.4103/0970-9185.155140
Item in Clipboard
Review
Perioperative chlorhexidine allergy: Is it serious?
J Anaesthesiol Clin Pharmacol.
2015 Apr-Jun.
Abstract
Chlorhexidine is an antiseptic agent, commonly used, in many different preparations, and for multiple purposes. Despite its superior antimicrobial properties, chlorhexidine is a potentially allergenic substance. The following is a review of the current evidence-based knowledge of allergic reactions to chlorhexidine associated with surgical and interventional procedures.
Keywords: Allergy; anesthesia; chlorhexidine; complications; perioperative.
Conflict of interest statement
Similar articles
-
Chlorhexidine allergy in the perioperative setting: a narrative review.Br J Anaesth. 2019 Jul;123(1):e95-e103. doi: 10.1016/j.bja.2019.01.033. Epub 2019 Apr 5. Br J Anaesth. 2019. PMID: 30955832 Review.
-
Chlorhexidine Allergy: Current Challenges and Future Prospects.J Asthma Allergy. 2020 Mar 9;13:127-133. doi: 10.2147/JAA.S207980. eCollection 2020. J Asthma Allergy. 2020. PMID: 32210588 Free PMC article. Review.
-
Anaphylactic reactions in anaesthetised patients - four cases of chlorhexidine allergy.Acta Anaesthesiol Scand. 2001 Nov;45(10):1290-4. doi: 10.1034/j.1399-6576.2001.451020.x. Acta Anaesthesiol Scand. 2001. PMID: 11736685
-
IgE-mediated chlorhexidine allergy: a new occupational hazard?Occup Med (Lond). 2009 Jun;59(4):270-2. doi: 10.1093/occmed/kqp042. Epub 2009 Mar 26. Occup Med (Lond). 2009. PMID: 19325161
-
Standardized testing with chlorhexidine in perioperative allergy--a large single-centre evaluation.Allergy. 2014 Oct;69(10):1390-6. doi: 10.1111/all.12466. Epub 2014 Aug 13. Allergy. 2014. PMID: 24957973
Cited by
-
Antiseptic efficacy of an innovative perioperative surgical skin preparation: A confirmatory FDA phase 3 analysis.Infect Control Hosp Epidemiol. 2020 Jun;41(6):653-659. doi: 10.1017/ice.2020.27. Infect Control Hosp Epidemiol. 2020. PMID: 32131912 Free PMC article. Clinical Trial.
-
Life-threatening Chlorhexidine Anaphylaxis: A Case Report.Malays Orthop J. 2017 Jul;11(2):72-74. doi: 10.5704/MOJ.1707.008. Malays Orthop J. 2017. PMID: 29021884 Free PMC article.
-
Chlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation.Transplant Cell Ther. 2021 Mar;27(3):262.e1-262.e11. doi: 10.1016/j.jtct.2021.01.004. Epub 2021 Jan 7. Transplant Cell Ther. 2021. PMID: 33781532 Free PMC article.
-
Clean or Dirty? A Systematic Review of Splash Basin Use and Its Infectious Potential in Orthopaedic Surgery.Iowa Orthop J. 2022;42(2):82-89. Iowa Orthop J. 2022. PMID: 36601221 Free PMC article.
-
A quality improvement project to assess the use of preventative measures against acute alveolar osteitis.BDJ Open. 2019 Jun 26;5:10. doi: 10.1038/s41405-019-0019-7. eCollection 2019. BDJ Open. 2019. PMID: 31258931 Free PMC article.
References
-
- Lang N, Brecx MC. Chlorhexidine digluconate-an agent for chemical plaque control and prevention of gingival inflammation. J Periodontal Res. 1986;21:74–89.
-
- Güthner T, Mertschenk B, Schulz B. Guanidine and Derivatives. Ullmann's Encyclopedia of Industrial Chemistry. Wiley Online Library. 2006
-
- Siebert J, Harke H.-P. Disinfectants. Ullmann's Encyclopedia of Industrial Chemistry. Wiley Online Library. 2009
-
- WHO. Model List of Essential Medicines. World Health Organization website. 2013
-
- Sánchez Palacios A, Ortiz Ponce M, Rodríguez Pérez A. Allergic reactions and pseudoallergies in surgical interventions with general anesthesia. Allergol Immunopathol (Madr) 2000;28:24–36. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources
